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Table 1 Characteristics of included studies for the meta-analyses

From: Log odds of positive lymph nodes as a novel prognostic predictor for colorectal cancer: a systematic review and meta-analysis

reference year single-center/multicenter clinical study design country patient year patient number age (years) population follow-up (mouth) follow-up Cutoff Groups in the study NOS score
number male/female LODDS0 LODDS1 LODDS2
Arslan NC [23] 2014 single-center prospective Turkey 2005-2011 440 253/167 median 66 (18–96) underwent curative resection of the colon for primary colon carcinoma median 30.6 (0– 88) OS LODDS0: ≤ − 1.36
LODDS1: − 1.36 to − 0.53
LODDS2: > − 0.53
182 146 99 8
Baqar AR [35] 2020 single-center retrospective Australia 2011-2016 856 402/454 median 73 (22–100) consecutive patients treated for colon adenocarcinoma median 27.1 (0.1–71) OS LODDS0: ≤ − 1.36
LODDS1: − 1.36 to − 0.53
LODDS2: > − 0.53
569 217 75 8
Fang HY [36] 2017 single-center retrospective China 2007-2010 192 113/79 median 59 (23-90) CRC patients who underwent curative (R0) resection median 65 (4-106) OS LODDS0: ≤ − 0.82
LODDS1: − 0.82 to − 0.57
LODDS2: > − 0.57
120 17 55 8
Fortea-Sanchis C [11] 2018 multicenter retrospective Spain 2004-2007 548 296/252 median 72 (63–80) diagnosed with colon cancer, undergoing surgery with curative intent, and had a complete anatomopathological report median 51 (30–64) OS, DFS LODDS0: ≤ − 2
LODDS1: − 2 to 1
LODDS2: >  1
349 187 12 8
Lee CW [37] 2016 single-center Retrospective American 1995-2013 164 97/67 median 55 (25–95) stage III rectal cancer patients who underwent curative resection NR OS LODDS0: ≤ − 1.2788
LODDS1: − 1.2788 to − 0.7105
LODDS2: > − 0.7105
73 43 48 8
Persiani R [24] 2012 single-center Retrospective Italy 2004-2008 236 98/138 NC colon cancer patients who had undergone surgical resection median 26 (2–76) OS LODDS0: ≤ − 1.36
LODDS1: − 1.36 to − 0.53
LODDS2: > − 0.53
93 79 42 6
Occhionorelli S [10] 2018 single-center Retrospective Italy 2003-2013 202 98/104 median 76 underwent urgent colonic resection for complicated colon cancer mean 64 (1–154) OS, DFS LODDS0: ≤ − 1.36
LODDS1: − 1.36 to − 0.53
LODDS2: > − 0.53
89 80 33 8
Ogawa T [38] 2015 single-center Retrospective Japan 1998-2011 117 54/63 Mean ± SD 61 ± 11 Stage IV CRC patients who underwent curative resection median 51 (4–185) OS, DFS LODDS0: ≤ −1.133
LODDS1: − 1.133 to −0.649
LODDS2: > − 0.649
39 39 39 8
Scarinci A [14] 2018 single-center Retrospective Italy 2010-2015 323 172/151 Mean ± SD 72 ± 11.2 patients with primary colon or rectal adenocarcinoma that underwent curative resection median 38 (6–67) OS LODDS0: ≤ −1.36
LODDS1: − 1.36 to −0.53
LODDS2: > − 0.53
165 85 73 8
Xu T [References] 2021 single-center Retrospective China 2004-2015 445 294/151 median 55 (23–81) patients with locally advanced rectal cancer who received Neoadjuvant chemoradiotherapy and underwent radical surgery median 46.7 (12.2– 148.7) DFS LODDS0: ≤ −1.1
LODDS1: − 1.1 to −0.6
LODDS2: > − 0.6
291 102 52 8
  1. Abbreviations: CRC Colorectal cancer, HR Hazard ratio, OS Overall survival, DFS Disease-free survival, LODDS Log odds of positive lymph nodes