Table 1 Characteristics of included studies for the meta-analyses
reference | year | single-center/multicenter | clinical study design | country | patient year | patient number | age (years) | population | follow-up (mouth) | follow-up | Cutoff | Groups in the study | NOS score | |||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
number | male/female | LODDS0 | LODDS1 | LODDS2 | ||||||||||||
Arslan NC [23] | 2014 | single-center | prospective | Turkey | 2005-2011 | 440 | 253/167 | median 66 (18–96) | underwent curative resection of the colon for primary colon carcinoma | median 30.6 (0– 88) | OS | LODDS0: ≤ − 1.36 LODDS1: − 1.36 to − 0.53 LODDS2: > − 0.53 | 182 | 146 | 99 | 8 |
Baqar AR [35] | 2020 | single-center | retrospective | Australia | 2011-2016 | 856 | 402/454 | median 73 (22–100) | consecutive patients treated for colon adenocarcinoma | median 27.1 (0.1–71) | OS | LODDS0: ≤ − 1.36 LODDS1: − 1.36 to − 0.53 LODDS2: > − 0.53 | 569 | 217 | 75 | 8 |
Fang HY [36] | 2017 | single-center | retrospective | China | 2007-2010 | 192 | 113/79 | median 59 (23-90) | CRC patients who underwent curative (R0) resection | median 65 (4-106) | OS | LODDS0: ≤ − 0.82 LODDS1: − 0.82 to − 0.57 LODDS2: > − 0.57 | 120 | 17 | 55 | 8 |
Fortea-Sanchis C [11] | 2018 | multicenter | retrospective | Spain | 2004-2007 | 548 | 296/252 | median 72 (63–80) | diagnosed with colon cancer, undergoing surgery with curative intent, and had a complete anatomopathological report | median 51 (30–64) | OS, DFS | LODDS0: ≤ − 2 LODDS1: − 2 to 1 LODDS2: >  1 | 349 | 187 | 12 | 8 |
Lee CW [37] | 2016 | single-center | Retrospective | American | 1995-2013 | 164 | 97/67 | median 55 (25–95) | stage III rectal cancer patients who underwent curative resection | NR | OS | LODDS0: ≤ − 1.2788 LODDS1: − 1.2788 to − 0.7105 LODDS2: > − 0.7105 | 73 | 43 | 48 | 8 |
Persiani R [24] | 2012 | single-center | Retrospective | Italy | 2004-2008 | 236 | 98/138 | NC | colon cancer patients who had undergone surgical resection | median 26 (2–76) | OS | LODDS0: ≤ − 1.36 LODDS1: − 1.36 to − 0.53 LODDS2: > − 0.53 | 93 | 79 | 42 | 6 |
Occhionorelli S [10] | 2018 | single-center | Retrospective | Italy | 2003-2013 | 202 | 98/104 | median 76 | underwent urgent colonic resection for complicated colon cancer | mean 64 (1–154) | OS, DFS | LODDS0: ≤ − 1.36 LODDS1: − 1.36 to − 0.53 LODDS2: > − 0.53 | 89 | 80 | 33 | 8 |
Ogawa T [38] | 2015 | single-center | Retrospective | Japan | 1998-2011 | 117 | 54/63 | Mean ± SD 61 ± 11 | Stage IV CRC patients who underwent curative resection | median 51 (4–185) | OS, DFS | LODDS0: ≤ −1.133 LODDS1: − 1.133 to −0.649 LODDS2: > − 0.649 | 39 | 39 | 39 | 8 |
Scarinci A [14] | 2018 | single-center | Retrospective | Italy | 2010-2015 | 323 | 172/151 | Mean ± SD 72 ± 11.2 | patients with primary colon or rectal adenocarcinoma that underwent curative resection | median 38 (6–67) | OS | LODDS0: ≤ −1.36 LODDS1: − 1.36 to −0.53 LODDS2: > − 0.53 | 165 | 85 | 73 | 8 |
Xu T [References] | 2021 | single-center | Retrospective | China | 2004-2015 | 445 | 294/151 | median 55 (23–81) | patients with locally advanced rectal cancer who received Neoadjuvant chemoradiotherapy and underwent radical surgery | median 46.7 (12.2– 148.7) | DFS | LODDS0: ≤ −1.1 LODDS1: − 1.1 to −0.6 LODDS2: > − 0.6 | 291 | 102 | 52 | 8 |