Octogenarian patients with colon cancer – postoperative morbidity and mortality are the major challenges

BMC Cancer

Table 7 Factors associated with relative long-term relative survival, among patients that survived 90 days; n = 976^a

Factor	Unadjusted hazard ratio (95% CI)	P value	Adjusted hazard ratio (95% CI)	P value
Age (years)
< 65	1 (reference)		1 (reference)
65—79	1.30 (0.84 to 2.03)	0.24	1.0005 (0.62 to 1.60)	0.998
≥ 80	0.58 (0.19 to 1.71)	0.32	0.73 (0.36 to 1.47)	0.38
Female sex	1.52 (0.98 to 2.36)	0.061	1.56 (1.03 to 2.36)	0.035
Calendar year
1980–1989	1 (reference)		1 (reference)
1990–1999	0.80 (0.47 to 1.35)	0.40	0.74 (0.44 to 1.24)	0.25
2000–2009	0.48 (0.28 to 0.85)	0.011	0.54 (0.31 to 0.93)	0.027
2010–2016	0.36 (0.18 to 0.70)	0.003	0.46 (0.25 to 0.85)	0.013
CCI	1.39 (1.14 to 1.68)	0.001	1.39 (1.12 to 1.73)	0.003
ASA score
1–2	1 (reference)		1 (reference)
3	1.85 (1.23 to 2.81)	0.003	1.64 (1.03 to 2.60)	0.036
4	5.45 (2.45 to 12.12)	< 0.001	4.79 (2.09 to 10.97)	< 0.001
Emergency surgery	3.07 (1.99 to 4.73)	< 0.001	2.13 (1.35 to 3.35)	0.001
Left vs. right colon	0.94 (0.62 to 1.43)	0.77	0.75 (0.49 to 1.14)	0.18
TNM-stage
I	1 (reference)		1 (reference)
II	3.92 (0.49 to 31.57)	0.20	1.98 (0.55 to 7.12)	0.30
III	16.81 (2.16 to 131)	0.007	8.17 (2.36 to 28.3)	0.001
R-status
R0—resection	1 (reference)		1 (reference)
R0—resection with perforation	9.78 (5.42 to 17.66)	< 0.001	4.81 (2.47 to 9.35)	< 0.001
R1—resection	3.54 (1.24 to 10.14)	0.018	3.25 (1.20 to 8.84)	0.021

^aPatients included those with stages I-III colon cancer during 1980–2016, treated with a major resection with curative intent (R0 and R1). Results are from a multivariable analysis; unadjusted: performed with one covariate at a time; adjusted: performed with all listed covariates included simultaneously. CCI Charlson Comorbidity Index, classified as 0, 1, 2, or 3 +

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