Table 2 Univariate and multivariate analysis of risk score and clinical factors with OS in the training cohort and validation cohort of TCGA and external validation cohort

Age

1.048 (1.021–1.075)

< 0.001

1.058 (1.031–1.086)

< 0.001

1.002 (0.977–1.028)

0.890

1.013 (0.985–1.042)

0.360

1.214 (0.321–2.312)

0.235

1.032 (0.231–2.913)

0.451

Gender

1.240 (0.772–1.993)

0.374

1.411 (0.858–2.319)

0.175

1.304 (0.728–2.335)

0.371

1.202 (0.667–2.169)

0.540

1.152 (0.489–2.182)

0.552

0.924 (0.451–3.521)

0.461

Grade

1.638 (1.031–2.601)

0.037

1.754 (1.080–2.846)

0.023

1.117 (0.676–1.845)

0.665

1.104 (0.655–1.861)

0.711

3.456 (1.224–5.050)

0.024

2.341 (0.219–7.121)

0.034

Stage

1.457 (1.099–1.933)

0.009

1.483 (1.085–2.027)

0.014

1.671 (1.209–2.308)

0.002

1.813 (1.281–2.565)

< 0.001

2.341 (0.512–5.641)

0.235

1.425 (0.248–7.214)

0.810

riskScore

1.674 (1.395–2.008)

< 0.001

1.798 (1.484–2.179)

< 0.001

1.513 (1.102–2.731)

0.007

1.872 (1.723–2.098)

0.04

2.424 (1.516–3.124)

0.013

1.915 (1.529–2.942)

0.040