Table 1 Results from data mining using GDC Data Portal, COSMIC, and cBioPortal are summarized here. The percentages of mutations in Direct DNA Repair genes and genes involved in Indirect DNA Stability as well as death rates in the TCGA BLCA tissue cohort are reported.
Direct DNA Repair | COSMIC | GDC Data Portal | cBioPortal | Death Rates (GDC Data Portal) |
|---|---|---|---|---|
ATM | 7.91% | 15.63% | 9% | Unavailable |
ERCC2 | 7.46% | 12.67% | 10% | Unavailable |
BRCA2 | 6.09% | 12.40% | 7% | Unavailable |
ATR | 1.19% | 10.24% | 5% | Unavailable |
PRKDC | 0 | 9.43% | 8% | Unavailable |
POLE | 1.49% | 7.28% | 5% | Unavailable |
FANCD2 | 1.64% | 7.01% | 9% | Unavailable |
FANCA | 2.24% | 6.74% | 6% | Unavailable |
SLX4 | 1.64% | 6.47% | 5% | Unavailable |
FANCM | 1.49% | 6.20% | 4% | Unavailable |
BRIP1 | 1.64% | 5.93% | 5% | Unavailable |
BRCA1 | 1.94% | 5.66% | 5% | Unavailable |
OGG1 | 0.30% | 3.50% | 7% | Unavailable |
NBN | 1.19% | 3.23% | 6% | Unavailable |
RAD54B | 1.04% | 1.89% | 6% | Unavailable |
DCLRE1C | 0.30% | 1.89% | 5% | Unavailable |
XPC | 0.30% | 1.62% | 5% | Unavailable |
NEIL2 | 0.15% | 1.35% | 6% | Unavailable |
Indirect DNA Stability | Â | Â | Â | Â |
TP53 | 28% | 55.26% | 48% | 44.39% |
POLQ | 1.49% | 10.24% | 5% | 36.84% |
CDK12 | 1.64% | 8.63% | 6% | 37.50% |
REV3L | 1.49% | 7.55% | 5% | 32.14% |
TP53BP1 | 1.34% | 7.01% | 5% | 26.92% |
CENPE | 2.39% | 6.47% | 4% | 41.67% |
MDC1 | 2.09% | 6.47% | 5% | 33.33% |
KNTC1 | 1.34% | 5.39% | 5% | 40% |
BUB1 | 1.04% | 5.12% | 5% | 21.05% |
RNF168 | 1.34% | 4.04% | 5% | 26.67% |
BAP1 | 1.34% | 4.04% | 5% | 40% |
RECQL4 | 0.45% | 4.04% | 5% | 40% |
POLN | 1.04% | 3.77% | 5% | 28.57% |
CLK2 | 0.30% | 3.50% | 5% | 23.08% |
WRN | 1.19% | 2.96% | 5% | 36.36% |
RRM2B | 0 | 1.35% | 9% | 40% |
TDP2 | 0.15% | 1.08% | 5% | 25% |
RAD18 | 0.45% | 0.81% | 6% | 33.33% |
RAD1 | 0.30% | 0.81% | 6% | 100% |
POLB | 0 | 0.27% | 5% | 0% |