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Table 1 Results from data mining using GDC Data Portal, COSMIC, and cBioPortal are summarized here. The percentages of mutations in Direct DNA Repair genes and genes involved in Indirect DNA Stability as well as death rates in the TCGA BLCA tissue cohort are reported.

From: PARP inhibitors chemopotentiate and synergize with cisplatin to inhibit bladder cancer cell survival and tumor growth

Direct DNA Repair COSMIC GDC Data Portal cBioPortal Death Rates (GDC Data Portal)
ATM 7.91% 15.63% 9% Unavailable
ERCC2 7.46% 12.67% 10% Unavailable
BRCA2 6.09% 12.40% 7% Unavailable
ATR 1.19% 10.24% 5% Unavailable
PRKDC 0 9.43% 8% Unavailable
POLE 1.49% 7.28% 5% Unavailable
FANCD2 1.64% 7.01% 9% Unavailable
FANCA 2.24% 6.74% 6% Unavailable
SLX4 1.64% 6.47% 5% Unavailable
FANCM 1.49% 6.20% 4% Unavailable
BRIP1 1.64% 5.93% 5% Unavailable
BRCA1 1.94% 5.66% 5% Unavailable
OGG1 0.30% 3.50% 7% Unavailable
NBN 1.19% 3.23% 6% Unavailable
RAD54B 1.04% 1.89% 6% Unavailable
DCLRE1C 0.30% 1.89% 5% Unavailable
XPC 0.30% 1.62% 5% Unavailable
NEIL2 0.15% 1.35% 6% Unavailable
Indirect DNA Stability     
TP53 28% 55.26% 48% 44.39%
POLQ 1.49% 10.24% 5% 36.84%
CDK12 1.64% 8.63% 6% 37.50%
REV3L 1.49% 7.55% 5% 32.14%
TP53BP1 1.34% 7.01% 5% 26.92%
CENPE 2.39% 6.47% 4% 41.67%
MDC1 2.09% 6.47% 5% 33.33%
KNTC1 1.34% 5.39% 5% 40%
BUB1 1.04% 5.12% 5% 21.05%
RNF168 1.34% 4.04% 5% 26.67%
BAP1 1.34% 4.04% 5% 40%
RECQL4 0.45% 4.04% 5% 40%
POLN 1.04% 3.77% 5% 28.57%
CLK2 0.30% 3.50% 5% 23.08%
WRN 1.19% 2.96% 5% 36.36%
RRM2B 0 1.35% 9% 40%
TDP2 0.15% 1.08% 5% 25%
RAD18 0.45% 0.81% 6% 33.33%
RAD1 0.30% 0.81% 6% 100%
POLB 0 0.27% 5% 0%