Pan-cancer analysis identifies BIRC5 as a prognostic biomarker

Fäldt Beding, Anna; Larsson, Peter; Helou, Khalil; Einbeigi, Zakaria; Parris, Toshima Z.

doi:10.1186/s12885-022-09371-0

BMC Cancer

Table 1 Genomic and transcriptomic datasets

From: Pan-cancer analysis identifies BIRC5 as a prognostic biomarker

Cancer type and pan-organ system	Cohort	Number of samples
		Genetic alterations^a	RNA-seq^a		Co-expression^a	KM plotter
		Genetic alterations^a	Cancer tissue	Normal tissue	Co-expression^a	KM plotter
Central nervous system
Glioblastoma multiforme	GBM	592	166	5	145
Brain lower grade carcinoma	LGG	514	530	0	511
Endocrine
Adrenocortical carcinoma	ACC	91	79	0	78
Thyroid carcinoma	THCA	500	496	58	480
Gastrointestinal
Cholangiocarcinoma	CHOL	36	36	9	36
Colon adenocarcinoma	COAD^b	594	191	0	524
Rectum adenocarcinoma	READ	594	72	0	524
Esophageal Adenocarcinoma	ESCA^c	182	185	11	181
Esophageal squamous carcinoma	ESCA^c	182	185	11	181
Liver hepatocellular carcinoma	LIHC	372	147	50	348
Pancreatic adenocarcinoma	PAAD	184	56	0	168
Stomach adenocarcinoma	STAD^f	440	415	35	407	875
Gynecologic
Breast invasive carcinoma	BRCA	1084	1026	108	994	1879
Cervical squamous cell carcinoma	CESC^d	297	159	0	275
Ovarian serous cystadenocarcinoma	OV	584	265	0	201	1656
Uterine corpus endometrial carcinoma	UCEC	529	369	0	507
Head and neck
Head and neck squamous cell carcinoma	HNSC	523	425	42	488
Hematologic and lymphatic malignancies
Diffuse Large B-cell Lymphoma	DLBC	41	48	0	37
Acute myeloid leukemia	LAML	200	173	0	165
Thymoma	THYM	123	120	0	119
Melanocytic
Skin cutaneous melanoma	SKCM	444	472	0	363
Uveal melanoma	UVM	80	80	0	80
Neural crest-derived
Pheochromocytoma and paraganglioma	PCPG	178	184	3	161
Soft tissue
Sarcoma	SARC	255	105	0	251
Uterine carcinosarcoma	UCS	57	57	0	56
Thoracic
Lung adenocarcinoma	LUAD^e	566	490	58	503	1925
Lung squamous cell carcinoma	LUSC^e	487	482	50	466	1925
Mesothelioma	MESO	87	87	0	82
Urologic
Bladder urothelial carcinoma	BLCA	411	223	19	402
Kidney chromophobe	KICH	65	66	25	65
Kidney renal clear cell carcinoma	KIRC	511	507	72	352
Kidney renal papillary cell carcinoma	KIRP	283	161	30	274
Prostate adenocarcinoma	PRAD	494	498	52	488
Testicular germ cell tumors	TGCT	145	156	0	144
Total		8812	8526	627	9351	6335

^aTCGA data, see Method
^bIn bioPortal COAD+READ was combined for our analysis
^cIn RNA-seq data esophageal adenocarcinoma and squamous carcinoma were combined. In analysis of RNA-seq data for gene co-expression there was only data for esophageal adenocarcinoma
^dWhen analyzing gene co-expression using the RNA-seq data, cervical squamous cell carcinoma and endocervical adenocarcinoma were both included
^eIn KM-plotter both LUAD and LUSC were included in analysis
^fStomach cancer was in KM plotter denominated as gastric cancer

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ISSN: 1471-2407

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