Application of One-Step Nucleic Acid Amplification (OSNA) in different cancer entities and usefulness in prostate cancer: a systematic review

Table 3 Characteristics of included studies

Group	Author	Year	Country	Tumour type	No. Patients	No. Nodes	Reference method	CK19 IHC	Analysis of discordant cases
1)	Tsujimoto et al. [15]	2007	Japan	Breast	101	325	H&E and IHC	yes	yes
	Feldman et al. [28]	2011	USA	Breast	496	1044	H&E and IHC	yes	yes
	Le Frère-Belda et al. [29]	2012	France	Breast	233	503	H&E and IHC	yes	yes
	Vegué et al. [30]	2012	Spain	Breast	57	567	H&E	yes	no
	Wang et al. [31]	2012	China	Breast	552	1188	H&E	no	yes
	Pathmanathan et al. [32]	2014	Australia	Breast	98	170	H&E and IHC	no	no
	Banerjee et al. [33]	2014	UK	Breast	170	268	H&E	no	no
	Li et al. [34]	2015	China	Breast	115	311	H&E	no	yes
2)	Croner et al. [35]	2010	Germany	Colorectal	184	184	H&E and IHC	yes	yes
	Yamamoto et al. [36]	2011	Japan	Colorectal	85	385	H&E	no	yes
	Guller et al. [37]	2012	Switzerland	Colorectal	22	313	H&E and IHC	yes	yes
	Yamamoto et al. [38]	2016	Japan	Colorectal	204	1925	H&E	no	no
	Yaguchi et al. [39]	2011	Japan	Gastric	32	162	H&E	no	yes
	Kumagai et al. [40]	2014	Japan	Gastric	61	394	H&E	no	yes
	Shimada et al. [41]	2019	Japan	Gastric	43	439	H&E	no	yes
3)	Okamoto et al. [42](29)	2013	Japan	Cervical	32	130	H&E	no	yes
	Nagai et al. [43]	2015	Japan	Endometrial	35	137	H&E	no	yes
	Fanfani et al. [44]	2018	Italy	Endometrial	40	110	H&E and IHC	yes	no
	Kost’un et al. [45](30)	2019	Czech Republic	Endometrial	58	135	H&E and IHC	yes	no
4)	Inoue et al. [46]	2012	Japan	Lung	49	165	H&E and IHC	no	no
	Nakagawa et al. [47]	2016	Japan	Lung	111	410	H&E	no	yes
	Escalante-Pérez et al. [48]	2019	Spain	Lung	160	705	H&E and IHC	yes	no
5)	Goda et al. [49]	2012	Japan	HNSCC	65	312	H&E	no	yes
5)	Sofía del Carmen et al. [50]	2016	Spain	Thyroid	37	267	H&E and IHC	yes	yes
6)	Engels et al. [24]	2021	Germany	Prostate	64	534	H&E and IHC	yes	yes

CK19 Cytokeratin 19, FN False negative, FP False positive, HNSCC Head and neck squamous cell carcinoma, H&E Hematoxylin and eosin, IHC Immunohistochemistry, No Number of, TN True negative, TP True positive

ISSN: 1471-2407