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Table 3 Characteristics of included studies

From: Application of One-Step Nucleic Acid Amplification (OSNA) in different cancer entities and usefulness in prostate cancer: a systematic review

Group Author Year Country Tumour type No. Patients No. Nodes Reference method CK19 IHC Analysis of discordant cases
1) Tsujimoto et al. [15] 2007 Japan Breast 101 325 H&E and IHC yes yes
Feldman et al. [28] 2011 USA Breast 496 1044 H&E and IHC yes yes
Le Frère-Belda et al. [29] 2012 France Breast 233 503 H&E and IHC yes yes
Vegué et al. [30] 2012 Spain Breast 57 567 H&E yes no
Wang et al. [31] 2012 China Breast 552 1188 H&E no yes
Pathmanathan et al. [32] 2014 Australia Breast 98 170 H&E and IHC no no
Banerjee et al. [33] 2014 UK Breast 170 268 H&E no no
Li et al. [34] 2015 China Breast 115 311 H&E no yes
2) Croner et al. [35] 2010 Germany Colorectal 184 184 H&E and IHC yes yes
Yamamoto et al. [36] 2011 Japan Colorectal 85 385 H&E no yes
Guller et al. [37] 2012 Switzerland Colorectal 22 313 H&E and IHC yes yes
Yamamoto et al. [38] 2016 Japan Colorectal 204 1925 H&E no no
Yaguchi et al. [39] 2011 Japan Gastric 32 162 H&E no yes
Kumagai et al. [40] 2014 Japan Gastric 61 394 H&E no yes
Shimada et al. [41] 2019 Japan Gastric 43 439 H&E no yes
3) Okamoto et al. [42](29) 2013 Japan Cervical 32 130 H&E no yes
Nagai et al. [43] 2015 Japan Endometrial 35 137 H&E no yes
Fanfani et al. [44] 2018 Italy Endometrial 40 110 H&E and IHC yes no
Kost’un et al. [45](30) 2019 Czech Republic Endometrial 58 135 H&E and IHC yes no
4) Inoue et al. [46] 2012 Japan Lung 49 165 H&E and IHC no no
Nakagawa et al. [47] 2016 Japan Lung 111 410 H&E no yes
Escalante-Pérez et al. [48] 2019 Spain Lung 160 705 H&E and IHC yes no
5) Goda et al. [49] 2012 Japan HNSCC 65 312 H&E no yes
Sofía del Carmen et al. [50] 2016 Spain Thyroid 37 267 H&E and IHC yes yes
6) Engels et al. [24] 2021 Germany Prostate 64 534 H&E and IHC yes yes
  1. CK19 Cytokeratin 19, FN False negative, FP False positive, HNSCC Head and neck squamous cell carcinoma, H&E Hematoxylin and eosin, IHC Immunohistochemistry, No Number of, TN True negative, TP True positive
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BMC Cancer

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