Table 3 Comparison of patients with germline TET2 mutation alone and not
Patient’s parameters | TET2 GM-Alone (n = 11) | TET2 GM-Others (n = 22) | P |
|---|---|---|---|
Age(Y)median(range) | 46(16–74) | 55.5(27–82) | 0.114 |
Male (%) | 7(63.6%) | 11(50.0%) | 0.712 |
VAF (%) median(range) | 50.23(48.2–54.16) | 50.70(47.5–55.0) | 0.611 |
Cytogenetics | 0.384 | ||
Normal or -Y alone | 6(54.5%) | 12(54.5%) | |
Complex | 0(0.0%) | 2(9.1%) | |
Others | 1(9.1%) | 5(22.7%) | |
unknown | 4(36.4%) | 3(13.6%) | |
Diagnosis | 0.026 | ||
MDS/AML | 2(18.2%) | 14(63.6%) | |
Others | 9(72.8%) | 8(22.7%) | |
Peripheral blood median(range) | |||
Hemoglobin (g/L) | 73(52–160) | 83(27.0–137) | 0.711 |
WBC (× 109/L) | 4.43(0.23–33.38) | 4.72(1.26–13.25) | 0.749 |
Platelet (×109/L) | 124(3–611) | 62(8–348) | 1 |
Absolute Neutrophils (× 109/L) | 1.83(0.0–25.37) | 1.53(0.19–8.86) | 0.711 |
Absolute Lymphocyte (×109/L) | 1.80(0.2–3.0) | 1.19(0.3–2.66) | 0.223 |
Absolute Monocyte (×109/L) | 0.23(0.0–0.83) | 0.24(0.0–0.760) | 0.863 |
Total Eosinophils (×109/L) | 0.2(0–1.0) | 0.01(0–0.49) | 0.065 |
Bone marrow (%) median (range) | |||
Myeloblast | 1(0.5–4.0) | 4(1.0–48) | 0.004 |
Mature Lymphocyte | 21(5.0–70.0) | 13.25(5.5–49) | 0.145 |
Mature Monocyte | 1.5(0.5–2.0) | 1.5(0.5–21.0) | 0.438 |
Basophilic Erythroblast | 1.5(0.5–2.0) | 1.5(0.5–5.0) | 0.71 |
Polychromatophilic erythroblast | 9.0(3.0–17.5) | 8.5(1.5–25.5) | 0.76 |
Acidophilic Erythroblast | 16.5(4–39) | 15.5(2.5–51.5) | 0.89 |