Table 2 Pedigree investigation information
Family No. | Patient No. | diagnosis | symptoms | co-mutate genes | Carriers of germline TET2 mutations in lineage relatives | Same mutation or not | carriers’ symptoms | carriers’ sample | Family history |
|---|---|---|---|---|---|---|---|---|---|
F1 | P1 | neutropenia | Fever | – | Sister (F 1-II-2) Mother (F 1-I-2) | Y | – | Hair/nail | – |
F11 | P11 | AML-M2 | Dizziness nasal bleeding | ZRSR2 (GM)KIT (SM) | Brother (F 11-II-4) Son (F 11-III-1) | Y | – | Hair/nail/PB | – |
F17 | P17 | MDS-SLD | Dizziness, fever nasal bleeding | – | Father (F 17-I-1) sister (F 17-II-4) | Y | – | Hair/nail | – |
F19 | P19 | MDS-EB2 | nasal bleeding | TP53 (SM) | Brother (F 19-II-3) | Y | – | Hair/nail | – |
F22 | P22 | MDS-EB2 | – | TP53 (SM)ETV6 (SM) | – | Y | – | Hair/nail | – |
F24 | P24 | MDS-SLD | Dizziness, fatigue | ZRSR2 (GM) ETV6 (SM) | Sister (F 24-II-3) Brother (F24-II-4) Daughter (F 24-III-1) Son (F 24-III-2) | Y | – | Hair/nail | – |
F25 | P25 | AA | Dizziness, fatigue | ZRSR2 (GM) | Sister (F 25-II-3) | Y | – | Hair/nail | – |
F28 | P28 | MDS-MLD | Fatigue, dizziness | NF1 (GM) | – | Y | Hair/nail | – | |
F31 | P31 | MDS-RAEB2 | Dizziness, fatigue | ZRSR2 (GM) | Sons (F 31-III-1/3) Grandson (F 31-IV-1) | Y | – | Hair/nail | – |