Patients | Disease-free survival | Overall survival | |||||
---|---|---|---|---|---|---|---|
Events | (%) | HR (95% CI) | Events | (%) | HR (95% CI) | ||
Gender | |||||||
Female | 246 | 112 | (45.5) | Ref | 93 | (37.8) | Ref |
Male | 679 | 334 | (49.2) | 1.07 (0.85–1.35) | 292 | (43.0) | 1.15 (0.89–1.48) |
Age (years) | |||||||
< 60 | 195 | 70 | (35.9) | Ref | 52 | (26.7) | Ref |
60–69 | 312 | 137 | (43.9) | 1.32 (0.98–1.77) | 115 | (36.9) | 1.55 (1.11–2.17) |
70–79 | 281 | 143 | (50.9) | 1.77 (1.31–2.37) | 132 | (47.0) | 2.28 (1.64–3.18) |
≥ 80 | 137 | 96 | (70.1) | 2.99 (2.14–4.16) | 86 | (62.8) | 3.82 (2.64–5.54) |
Smoking habits | |||||||
Never | 178 | 81 | (45.5) | Ref | 69 | (38.8) | Ref |
Ever | 655 | 333 | (50.8) | 1.33 (1.01–1.44) | 279 | (42.6) | 1.35 (1.00–1.83) |
Missing | 92 | 42 | (46.6) | 37 | (40.2) | - | |
Drinking habits | |||||||
Never | 453 | 219 | (48.3) | Ref | 183 | (40.4) | Ref |
Ever | 319 | 157 | (49.2) | 1.14 (0.90–1.43) | 138 | (43.3) | 1.24 (0.97–1.59) |
Missing | 153 | 70 | (45.8) | 64 | (41.8) | - | |
Cancer site | |||||||
Oral cavity | 413 | 199 | (48.2) | 1.31 (0.92–1.87) | 175 | (42.4) | 1.69 (1.13–2.54) |
Oropharynx | 93 | 43 | (46.2) | Ref | 32 | (34.4) | Ref |
Hypopharynx | 60 | 36 | (60.0) | 1.60 (0.99–2.56) | 33 | (55.0) | 1.84 (1.10–3.10) |
Larynx | 359 | 168 | (46.8) | 1.26 (0.87–1.81) | 145 | (40.4) | 1.52 (1.00–2.30) |
pT | |||||||
pT1 | 93 | 35 | (37.6) | Ref | 24 | (25.8) | Ref |
pT2 | 320 | 145 | (45.3) | 1.31 (0.89–1.93) | 122 | (38.1) | 1.71 (1.09–2.71) |
pT3 | 220 | 103 | (46.8) | 1.55 (1.03–2.34) | 86 | (39.1) | 1.90 (1.18–3.08) |
pT4 | 282 | 158 | (56.0) | 1.83 (1.23–2.72) | 148 | (52.5) | 2.52 (1.58–4.02) |
Missing | 10 | 5 | (50.0) | 5 | (50.0) | - | |
pN | |||||||
pN0 | 534 | 212 | (39.7) | Ref | 138 | (32.5) | Ref |
pN1 | 121 | 68 | (56.2) | 1.67 (1.23–2.26) | 59 | (49.6) | 1.72 (1.23–2.40) |
pN2-pN3 | 265 | 162 | (61.1) | 1.93 (1.42–2.64) | 144 | (56.1) | 2.12 (1.51–2.97) |
Missing | 5 | 4 | (80.0) | 3 | (60.0) | - | |
Grading | |||||||
G1 | 93 | 37 | (39.8) | Ref | 32 | (34.4) | Ref |
G2 | 469 | 211 | (45.0) | 1.30 (0.90–1.77) | 180 | (38.4) | 1.21 (0.81–1.80) |
G3 | 303 | 166 | (54.8) | 1.43 (0.97–2.12) | 144 | (47.5) | 1.32 (0.87–2.01) |
Missing | 60 | 32 | (53.3) | 29 | (48.3) | ||
Surgical margins | |||||||
Negative | 610 | 263 | (43.1) | Ref | 224 | (36.7) | Ref |
Close/positive | 243 | 140 | (57.6) | 1.31 (1.05–1.63) | 120 | (49.4) | 1.27 (1.00–1.62) |
Missing | 72 | 43 | (59.7) | 41 | (56.9) | ||
Extranodal extension | |||||||
Absent | 765 | 336 | (43.9) | Ref | 283 | (37.0) | Ref |
Present | 160 | 110 | (68.8) | 1.34 (1.00–1.79) | 102 | (63.8) | 1.41 (1.04–1.92) |
Adjuvant (chemo) radiotherapy | |||||||
No | 454 | 198 | (43.6) | Ref | 164 | (36.1) | Ref |
Yes | 463 | 241 | (52.1) | 0.76 (0.58–1.01) | 214 | (46.2) | 0.81 (0.60–1.10) |
Missing | 8 | 7 | (87.5) | 7 | (87.5) |