Long-term cognitive, psychosocial, and neurovascular complications of unilateral head and neck irradiation in young to middle-aged adults

Table 4 Association of cognitive impairment with fatigue, speech problems, vascular white matter hyper-intensities, and brain parenchymal fraction

Characteristic	Cognitive impairment (n = 10), median [IQR]	No cognitive impairment (n = 19), median [IQR]	P-value^a
Fatigue (CIS-20R, Z-score)	1.74 [1.50—2.43]	1.99 [1.79—2.25]	0.70
Speech problems (SHI, Z-score)	1.59 [-0.43—4.20]	-0.43 [-0.43—2.39]	0.13
WMH, mL	0.15 [0.00—0.39]	0.09 [0.00—0.51]	0.70
BPF	0.79 [0.77—0.79]	0.78 [0.77—0.78]	0.21

^a Not Benjamini–Hochberg adjusted p-values are shown. CIS-20R Checklist Individual Strength-20R, SHI Speech Handicap Index, WMH white matter hyperintensities, BPF brain parenchymal fraction

ISSN: 1471-2407