Table 2 Univariate and multivariate analyses of overall survival
From: A Comprehensive Prognostic Analysis of POLD1 in Hepatocellular Carcinoma
Variables | Univariate analysis | Multivariate analysis | ||
|---|---|---|---|---|
HR (95% CI) | P | HR (95% CI) | P | |
Age (≥ 65 vs. < 65) | 1.23(0.85,1.78) | 0.273 | - | - |
Gender (Female vs. Male) | 1.26(0.87,1.84) | 0.228 | - | - |
Family history of cancer (Yes vs. No) | 1.14(0.76,1.69) | 0.53 | - | - |
TNM stage (II vs. I) | 1.42(0.87,2.32) | 0.16 | 1.21(0.64,2.28) | 0.556 |
TNM stage (III vs. I) | 2.72(1.78,4.15) | < 0.001 | 1.91(1.11,3.3) | 0.02 |
TNM stage (IV vs. I) | 5.44(1.68,17.63) | 0.005 | 6.57(2,21.63) | 0.002 |
Histologic grade (G3–G4 vs. G1–G2) | 1.14(0.78,1.67) | 0.489 | - | - |
Ishak score (5–6 vs. 0–4) | 0.87(0.5,1.5) | 0.612 | - | - |
Child–Pugh grade (B–C vs. A) | 1.66(0.82,3.36) | 0.159 | - | - |
Vascular invasion (Micro vs. None) | 1.16(0.72,1.88) | 0.539 | 1(0.57,1.75) | 0.989 |
Vascular invasion (Macro vs. None) | 2.52(1.14,5.58) | 0.023 | 2.02(0.88,4.62) | 0.097 |
Alpha fetoprotein (Positive vs. Negative) | 1.45(0.92,2.28) | 0.108 | - | - |
Residual tumor (R1–R2 vs. R0) | 1.17(0.43,3.2) | 0.754 | - | - |
POLD1 (High vs. Low) | 1.58(1.23,2.02) | < 0.001 | 1.47(1.1,1.97) | 0.01 |