Stereotactic body radiation therapy as a salvage treatment for single viable hepatocellular carcinoma at the site of incomplete transarterial chemoembolization: a retrospective analysis of 302 patients

Table 2 Univariate and multivariate analysis of prognostic factor for local control

Variables	Univariate		Multivariate
Variables	HR (95% CI)	p value	HR (95% CI)	p value
Age	0.99 (0.95–1.03)	0.513		–
ECOG PS		0.455		–
0	Reference
1–2	0.47 (0.06–3.45)
Child-Pugh class		-^a		–
A
B
Etiology		0.322		–
HBV	Reference
Others	0.58 (0.20–1.70)
BCLC stage		0.013		0.290
0	Reference		Reference
A	3.23 (1.29–8.09)		1.87 (0.59–5.91)
Tumor size	1.82 (1.32–2.53)	< 0.001	1.78 (1.21–2.62)	0.004
Alpha-fetoprotein		0.376		–
≤ 20 ng/mL	Reference
> 20 ng/mL	1.44 (0.65–3.20)
Number of prior treatment sessions	1.07 (0.98–1.16)	0.156	1.01 (0.94–1.10)	0.735
BED	0.95 (0.92–0.98)	0.004	0.97 (0.94–1.00)	0.073
CR at 3 months		0.777		–
Yes	Reference
No	1.13 (0.50–2.56)
anyCR^b		< 0.001		< 0.001
Yes	Reference		Reference
No	22.48 (8.06–62.68)		15.58 (5.06–47.93)

Abbreviations: HR hazard ratio, CI confidence interval, ECOG PS Eastern Cooperative Oncology Group performance status, BED biologically effective dose, CR complete response
^aNo valid analysis was performed because there was no local failure in the Child-Pugh class B group
^bAchievement of complete response according to the mRECIST criteria at the time point of the best response during the entire follow-up period

ISSN: 1471-2407