Table 3 Patient-Reported Outcomes Related to Distress

Ruberg et al 2016 [47]

N = 180 (Total)

N = 16 (Abnormal)

• Age: 30–60 years

• Women living in Netherlands

Prospective longitudinal

TVS/CA125

IES-intrusive

Total (Abnormal, Normal)

3.5 (5.6)

3.1 (5.0)

2.4 (4.8)

Abnormal

2.9 (4.4)

3.7 (4.7)

6.3 (6.4)

Normal

3.6 (5.7)

3.0 (5.1)

2.1 (4.4)*^,a

van den Bergh et al 2011 [48]

N = 600–658

• Age: 50–75 years

• NELSON study participants

RCT

LDCT

IES (total)

Indeterminate

4.0 (2.8–5.3)

7.8 (6.5–9.0)*^b

(−)

4.1 (3.4–4.8)

2.6 (2.0–3.3)

IES-intrusive

Indeterminate

1.9 (1.3–2.4)

3.4 (2.8–3.9)

(−)

1.7 (1.4–2.0)

1.0 (0.7–1.3)

IES-avoidance

Indeterminate

2.2 (1.4–3.0)

4.4 (3.6–5.2)

(−)

2.3 (1.9–2.8)

1.7 (1.2–2.1)

van den Bergh et al 2010 [41]

N = 600–641

• Age: 50–75 years

• NELSON study participants

RCT

LDCT

IES (total)

Indeterminate

4.5 (6.5)

4.9 (8.4)

8.3 (11.3)*^,c

(−)

4.1 (7.4)

4.5 (7.7)

2.4 (5.5)*^d

IES-intrusive

Indeterminate

2.0 (3.0)

2.0 (3.8)

3.5 (5.2)

(−)

1.7 (3.5)

1.8 (3.5)

0.8 (2.4)

IES-avoidance

Indeterminate

2.5 (4.1)

2.9 (4.9)

4.8 (6.9)*^c

(−)

2.4 (3.7)

2.7 (4.7)

1.5 (3.7)

van den Bergh et al 2008 [43]

N = 288–324

• Age: 50–75 years

• NELSON study participants

RCT

LDCT

IES (total)

Total (−/Incidental)

3.0^e

1.0^e

IES-intrusive

1.0^e

0.0^e

IES-avoidance

1.0^e

0.0^e

Bunge et al 2008 [49]

N = 40–47 (High AR)

N = 236–247 (Low AR)

• Age: 50–75 years

• NELSON study participants

RCT

LDCT

IES (total)

High AR

11.5^e

Low AR

2.0^e

IES-intrusive

High AR

5.0^e

Low AR

1.0^e

IES-avoidance

High AR

5.0^e

Low AR

1.0^e