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Table 4 Multivariate Cox regression of factors influencing breast cancer-specific survive in patients with PABC and non-PABC

From: Clinical characteristics, pregnancy outcomes and ovarian function of pregnancy-associated breast cancer patients: a retrospective age-matched study

Variable

Level

Events

Total

Univariate model

Multivariate model

HR

95%CI

p

HR

95%CI

p

PABC

Yes

13

63

2.925

1.277 ~ 6.701

0.011

1.230

0.460 ~ 3.290

0.681

No

10

126

1

     

Age at

diagnosis

 ≤ 35

16

133

1.009

0.414 ~ 2.456

0.985

   

 > 35

7

56

1

     

Family history

Yes

4

18

2.222

0.747 ~ 6.615

0.151

2.113

0.555 ~ 8.049

0.273

No

19

171

1

     

TNM stage

III/IV

18

48

15.741

5.810 ~ 42.646

 < 0.001

30.875

7.232 ~ 131.820

 < 0.001

0/I/II

5

141

1

     

ER

 + 

12

120

0.543

0.240 ~ 1.233

0.144

1766.341

0.000 ~ 3.509*107

0.931

-

11

69

1

     

PR

 + 

10

108

0.530

0.231 ~ 1.216

0.134

1.111

0.174 ~ 7.081

0.912

-

13

81

1

     

HR

 + 

12

124

0.494

0.218 ~ 1.211

0.092

0.000

0.000 ~ 3.365*106

0.920

-

11

65

1

     

Her-2

 + 

17

120

1.842

0.725 ~ 4.683

0.199

2.844

0.845 ~ 9.565

0.091

-

6

69

1

     

Ki-67

 ≥ 14%

19

149

1.813

0.612 ~ 5.371

0.283

   

 < 14%

4

40

1

     

Breast surgery

BMS

19

156

1.317

0.440 ~ 3.938

0.622

   

CMS

4

33

      

Chemotherapy

No

1

9

1

     

ACT

13

142

0.529

0.068 ~ 4.089

0.542

   

NACT + ACT

9

38

2.141

0.270 ~ 16.958

0.471

   

Radiotherapy

Yes

18

101

3.289

1.219 ~ 8.874

0.019

1.105

0.356 ~ 3.434

0.865

No

5

88

1

     

Endocrine

therapy

Yes

4

106

0.134

0.045 ~ 0.394

 < 0.001

0.200

0.049 ~ 0.818

0.025

No

19

83

1

     

Targeted

therapy

Yes

2

46

0.356

0.083 ~ 1.520

0.163

0.143

0.028 ~ 0.743

0.021

No

21

143

1

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