Table 3 Clinicopathological characteristics of patients with dMMR profile
CASE | 1 | 2 | 3 | 4 | 5 | 6 | 7 |
|---|---|---|---|---|---|---|---|
SECOND PRIMITIVE CANCER | COLON | / | BREAST | / | / | / | / |
FAMILY HISTORY | DAUGHTER (RECTAL −37 y.o.) MOTHER (RENAL) | FATHER (LUNG) MOTHER(OVARIAN) BROTHER (PANCREATIC 47 y.o.) | / | / | MATHER(ENDOMETRIAL) MATERNAL GRANDFATHER (COLON) MATERNAL AUNT (ENDOMETRIAL) MATERNAL COUSIN (ENDOMETRIAL) | / | / |
HISTOLOGY | UCa | UC | UC | UC | UC | UC | UC |
AGE | 65 | 62 | 70 | 82 | 57 | 55 | 64 |
SITE | PELVIS | PELVIS | PELVIS | PELVIS | URETHER | URETHER | URETHER |
MSS/MSI | MSS | MSS | MSS | MSS | MSI-H | MSI-L | MSI-L |
NECTIN-4 | MEDIUM | LOW | MEDIUM | LOW | LOW | MEDIUM | NEGATIVE |
MMR lost | MSH2/MSH6 | MSH2/MSH6/PMS2 | MLH1/MSH2/MSH6/PMS2 | MLH1/MSH2/MSH6/PMS2 | MSH2/MSH6 | EQUIVOCAL | EQUIVOCAL |