Diagnostic performance of MRI, SPECT, and PET in detecting renal cell carcinoma: a systematic review and meta-analysis

Table 2 Results of Subgroup analysis

Subgroups	Sensitivity	I² of sensitivity (%)	Q value of sensitivity	p of sensitivity	Specificity	I² of specificity (%)	Q value of specificity	p of specificity	PLR	NLR	DOR	SROC Curve AUC
MRI at 1.5 T	0.86 [0.64, 0.96]	92.11	63.39	< 0.001	0.94 [0.76, 0.99]	75.77	20.63	< 0.001	15.2 [3.3, 70.0]	0.15 [0.05, 0.42]	104 [18, 604]	0.96 [0.94, 0.98]
Prospective studies
MRI	0.88 [0.81, 0.93]	26.43	5.44	0.25	0.91 [0.71, 0.98]	80.70	20.72	< 0.001	10.2 [2.7, 38.4]	0.13 [0.08, 0.22]	79 [15, 403]	0.90 [0.88, 0.93]
PET	0.90 [0.56, 0.98]	96.19	157.33	< 0.001	0.93 [0.54, 0.99]	64.60	16.95	0.01	12.6 [1.4, 117.3]	0.11 [0.02, 0.63]	119 [5, 2597]	0.97 [0.95, 0.98]
Primary RCC
MRI	0.76 [0.65, 0.85]	79.90	59.70	< 0.001	0.88 [0.81, 0.93]	66.50	35.82	< 0.001	6.4 [4.3, 9.7]	0.27 [0.18, 0.39]	24 [16, 37]	0.90 [0.87, 0.92]
PET	0.77 [0.55, 0.91]	89.86	88.73	< 0.001	0.80 [0.60, 0.91]	0	5.37	0.80	3.8 [1.8, 7.9]	0.28 [0.13, 0.61]	13 [4, 45]	0.84 [0.80, 0.87]
PET/CT	0.80 [0.64, 0.90]	82.35	28.33	< 0.001	0.85 [0.73, 0.93]	20.38	6.28	0.28	5.5 [2.8, 10.8]	0.23 [0.11, 0.46]	24 [7, 78]	0.89 [0.85, 0.91]

RCC renal cell carcinoma, MRI magnetic resonance imaging, PET positron emission tomography, CT computerized tomography, PLR positive likelihood ratio, NLR negative likelihood ratio, DOR diagnostic odds ratio, SROC summary receiver operating characteristic, AUC area under the SROC curve

ISSN: 1471-2407