Fig. 4

Relative risk of ER positive and ER negative postmenopausal breast cancer by relative body size at age 10 years and body mass index (BMI) at around 60 years among women who had never used menopausal hormone therapy. [1] Relative risks associated with categories of self-reported body size at age 10 are plotted against mean BMI measured at age 11 years in a subsample of participants who were also included in the National Survey of Health and Development cohort. Relative risks associated with categories of self-reported BMI at around age 60 are plotted against mean BMI measured in the subsample of participants around 6 years later. [2] Relative risks were stratified by year of birth, year of baseline, and region, and adjusted for social deprivation, education, adult height, first-degree family history of breast cancer, smoking, exercise, alcohol consumption, age at menarche, parity and age at first birth, use of oral contraceptives, age at menopause, and mutually for body size at age 10 and around age 60 years. Confidence intervals are represented as group-specific confidence intervals (g-s CIs, see Methods); analyses were restricted to never users of menopausal hormone therapy.