Fig. 8

The relationship between TYROBP network and immune-related genes in OS and the schematic workflow of the whole study. A-B The Venn diagram representing the overlapping between downregulated genes in OS, TYROBP positively correlated genes in OS, and immune related genes (i.e., immune stimulators, MHC molecules, chemokines in A, and immune inhibitors in B). C The working model representing the TNF-α-SPI1-TYROBP network pathway across cancer types, which can regulate immune infiltration and CD8⁺ T cell activation. D Workflow for the whole study as to how to identify the SPI1-TYROBP-FCER1G network and its association with immune microenvironment