Fig. 7

The key transcription factor SPI1 in the conserved SPI1-TYROBP-FCER1G network. A The Venn diagram representing the numbers of ChEA3 predicted transcription factors/SPI1 binding genes and TYROBP network genes. B GSEA plot showing significant enrichment of PU.1 and IRF binding motifs in TYROBP positively co-expressed genes. C The genomic signal density around TYROBP showing the PU.1 binding regions upstream and the mRNA level of TYROBP. D Kaplan–Meier plots of overall survival according to expressional level of SPI1 (median cutoff). E GSEA plot showing the significant enrichments of signaling pathways including TNF-α signaling via NF-κB in TYROBP positively co-expressed genes. F Drug pairs found by Drug Pair Seeker representing the cytokine pairs including TNF-α that can upregulate the TYROPB network