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Table 4 Cox proportional hazards model for overall survival

From: Effect of prior antibiotic or chemotherapy treatment on immunotherapy response in non-small cell lung cancer

  Alive (n = 84) Deceased (n = 172) Univariate Multivariate1
  N (%) N (%) Hazard Ratio
(95% CI)
Hazard Ratio (95% CI) P-value
Antibiotic Use
 ABT- 70 (83.3) 140 (81.4) 1.00 1.00  
 ABT +  14 (16.7) 32 (18.6) 1.33 (0.91–1.96) 1.35 (0.91–2.02) 0.140
PPI Use
 No 62 (73.8) 133 (77.3) 1.00 1.00  
 Yes 22 (26.2) 39 (22.7) 0.91 (0.63–1.29) 0.92 (0.64–1.33) 0.667
Prior Chemotherapy
 No 44 (52.4) 66 (38.4) 1.00 1.00  
 Yes 40 (47.6) 106 (61.6) 1.42 (1.04–1.93) 1.47 (1.07–2.03) 0.018*
Age (mean [sd])
 NA 65.6 [10.1] 65.4 [9.2] 1.00 (0.99–1.02) 1.00 (0.98–1.02) 0.933
ECOG Performance Status
 0 24 (28.6) 33 (19.3) 1.00 1.00  
 1/2 60 (71.4) 138 (80.7) 1.75 (1.19–2.57) 1.75 (1.19–2.57) 0.005*
Targeted Therapy
 No 73 (86.9) 142 (82.6) 1.00 1.00  
 Yes 11 (13.1) 30 (17.4) 1.02 (0.69–1.52) 1.00 (0.66–1.52) 0.995
Smoking Status
 Never 13 (15.5) 25 (14.5) 1.00 1.00  
 Former 57 (67.9) 127 (73.8) 1.30 (0.85–2.00) 1.36 (0.88–2.10) 0.168
 Current 14 (16.7) 20 (11.6) 1.02 (0.57–1.84) 1.06 (0.58–1.92) 0.859
  1. *Statistically Significant, when p < 0.05; 1: Adjusted for PPI, Chemotherapy, Age (Continuous), ECOG (0 vs. combined 1/2), Targeted Therapy, and Smoking Status; *Dead considered as event/1. Alive is reference/0. PPI: Proton pump inhibitor