| |
Univariable analyses
|
Multivariable analyses
|
|---|
|
HR
|
95% CI
|
P-Value
|
HR
|
95% CI
|
P-Value
|
|---|
|
Sex
|
|
Male
|
1
|
reference
| |
1
|
reference
| |
|
Female
|
0.935
|
0.733–1.193
|
0.590
|
0.876
|
0.664–1.155
|
0.349
|
|
Age (years)
|
|
≤ 60
|
1
|
reference
| |
1
|
reference
| |
|
> 60
|
1.342
|
1.083–1.662
|
0.007
|
1.264
|
1.018–1.569
|
0.034
|
|
Drinking history
|
|
No
|
1
|
reference
| |
1
|
reference
| |
|
Yes
|
1.421
|
1.134–1.780
|
0.002
|
1.673
|
1.303–2.149
|
< 0.001
|
|
Tumor length (continuous)
|
1.007
|
0.941–1.078
|
0.832
| | | |
|
NELNs
|
|
≤ 15
|
1
|
reference
| |
1
|
reference
| |
|
> 15
|
0.630
|
0.506–0.784
|
< 0.001
|
0.566
|
0.445–0.720
|
< 0.001
|
|
Tumor differentiation
|
|
Well
|
1
|
reference
| |
1
|
reference
| |
|
Moderate
|
1.088
|
0.833–1.420
|
0.537
|
1.057
|
0.808–1.383
|
0.687
|
|
Poor
|
1.500
|
1.110–2.026
|
0.008
|
1.812
|
1.334–2.461
|
< 0.001
|
|
pT stage
|
|
T1
|
1
|
reference
| |
1
|
reference
| |
|
T2
|
1.132
|
0.776–1.652
|
0.520
|
1.236
|
0.840–1.819
|
0.283
|
|
T3
|
1.584
|
1.130–2.221
|
0.008
|
1.856
|
1.312–2.626
|
< 0.001
|
|
Tumor Location
|
|
Upper
|
1
|
reference
| |
1
|
reference
| |
|
Middle
|
0.960
|
0.665–1.386
|
0.828
|
0.899
|
0.605–1.305
|
0.547
|
|
Lower
|
0.659
|
0.460–0.946
|
0.024
|
0.491
|
0.331–0.729
|
< 0.001
|
|
Smoking history
|
|
No
|
1
|
reference
| | | | |
|
Yes
|
1.087
|
0.871–1.358
|
0.461
| | | |
|
Surgical approaches
|
|
Sweet
|
1
|
reference
| |
1
|
reference
| |
|
Ivor-Lewis
|
1.922
|
1.174–3.144
|
0.009
|
1.568
|
0.948–2.595
|
0.080
|
|
McKeown
|
0.782
|
0.602–1.017
|
0.066
|
0.749
|
0.543–1.033
|
0.078
|
|
Other
|
0.790
|
0.390–1.599
|
0.512
|
0.815
|
0.400–1.661
|
0.573
|
|
Transthoracic laterality
|
|
Left
|
1
|
reference
| | | | |
|
Right
|
0.856
|
0.673–1.088
|
0.204
| | | |
|
Other
|
0.879
|
0.218–3.536
|
0.855
| | | |
|
Two-field dissection
|
|
No
|
1
|
reference
| |
1
|
reference
| |
|
Yes
|
0.979
|
0.687–1.396
|
0.907
|
0.930
|
0.543–1.593
|
0.791
|
|
Three-field dissection
|
|
No
|
1
|
reference
| |
1
|
reference
| |
|
Yes
|
1.063
|
0.669–1.689
|
0.797
|
1.366
|
0.658–2.836
|
0.403
|
- HR hazard ratio, CI confidence interval, NELN the number of examined lymph node; Cox regression’s method was Enter selection
