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Table 2 AAT genotype and adjusted risk of LC

From: Alpha-1 antitrypsin deficiency and risk of lung cancer in never-smokers: a multicentre case–control study

Variable

Cases, n (%)

Controls, n(%)

Adjusted ORa (95% CI)

Adjusted ORb (95% CI)

AAT

457 (42)

631 (58)

  

MM

279 (73.0)

337 (66.7)

1 (-)

1 (-)

MS

80 (20.9)

137 (27.1)

0.67 (0.49–0.91)

0.66 (0.48–0.91)

MZ

10 (2.6)

18 (3.6)

0.79 (0.37–1.6)

0.64 (0.28–1.4)

SZ

4 (1.0)

4 (0.8)

1.09 (0.25–4.69)

0.9 (0.21–3.91)

SS

9 (2.4)

9 (1.8)

1.09 (0.42 -2.78)

1.1 (0.42–2.89)

ETS

    

No

226 (59.2)

302 (59.8)

-

1 (-)

Yes

156 (40.8)

203 (40.2)

-

0.88 (0.66–1.17)

Radon exposure

    

 < 200 Bq/m3

220 (57.6)

315 (62.4)

-

1 (-)

 > 200 Bq/m3

162 (42.4)

190 (37.6)

-

1.24 (0.94 -1.64)

  1. aAdjusted for age and sex
  2. bAdjusted for age, sex, and exposure to ETS and residential radon
  3. ETS environmental tobacco smoke, AAT alpha-1 antitrypsin