Table 6 Studies with cohorts of Stage IV/metastatic WT that reported subgroup outcome of patients with LM (only studies reporting > 5 patients with LM)
Authors | Study Type | Year of Publication | Recruitment period | Study population | Number of patients with LM | WTLM with high-risk histology | Local treatment of LM | Outcomes | ||
|---|---|---|---|---|---|---|---|---|---|---|
Breslow et al. | ROS-OncReg | 1986 | 1969-1983 | 480 patients with Stage IV or metastatic WT Sync: 236 with lung and/or liver M Meta: 244 with relapse in lung and/or liver | 69 Sync: 36 Meta: 33 | 15 (22%) Sync: 4 (11%) Meta: 11 (33%) | RT and/or surgery (numbers unknown) | LM (all): OS 39% (SD 5) Sync LM: OS 64% (SD 8) All sync patients: OS 67% (SD 3) Meta LM: OS 12% (SD 6) All meta patients: OS 40% (SD 3) | ||
Varan et al. | ROS-SC | 2005 | 1971-2002 | 57 patients with Stage IV WT (sync only, different metastatic sites) | 12 (sync only) | 3 (25%) | RT only | LM (all): OS 17% (SD 11) All Stage IV patients: OS 37% (SD 6) M lung only: OS 50% (SD 7) | ||
Fuchs et al. | ROS-OncReg | 2008 | 1994-2004 | 45 patients with WTLM Sync: 29 Stage IV Meta: 26 relapsed | 45 Sync: 29 Meta: 16 | 9 (20%) Sync: 4 (14%) Meta: 5 (31%) | Surgery: 21 RT: 23 | LM (all): OS 53% (SD 7) Sync: OS 59% (SD 9) Meta: OS 44% (SD 12) | ||
Ehrlich et al. | ROS-OncReg | 2009 | 1986-2002 | 96 patients with WTLM (sync only) | 96 (sync only) | 0 | Surgery: 25 RT: 26 | LM (all): OS 72% (SD 6) | ||
Berger et al. | ROS-MC | 2013 | 1994-2011 | 31 patients with stage IV WT (sync only, different metastatic sites) | 6 (sync only) | 3 (50%) | Surgery: 2 RT: 0 | LM (all): OS 50% (SD 20) All stage IV patients: OS 82% (SD 7) | ||
Aronson et al. | ROS-SC | 2016 | 2002-2010 | 45 patients with stage IV WT (sync only) | 19 (sync only) | 9 (47%) | Surgery: 3 RT: 0 | LM (all): OS 47% (SD 11) All stage IV patients: OS 59% (SD 7) | ||
Jain et al. | ROS-SC | 2020 | 2000-2012 | 36 patients with Stage IV WT, lung and/or liver M (sync only) | 8 (sync only) | 1 (13%) | RT only | LM (all): OS 13% (SD 12) All Stage IV patients: OS 50% (SD 8) | ||
Liné et al. | ROS-OncReg | 2020 | 2002-2012 | 18 patients with WTLM (sync only) | 18 (sync only) | 4 (22%) | Surgery:16 RT: 6 | LM (all): OS 89% (SD 7) | ||
Pooled data | 808 | 273 Sync: 224 Meta: 49 | 44 Sync: 28 (13%, SD 5) Meta: 16 (33%, SD 7) → p < 0.001 | Weighted mean OS (LM all): 55% (SD 24) LM Sync: 63% (SD 27) LM Meta: 23% (SD 9) → p < 0.001 | ||||||