Microsatellite instability is biased in Amsterdam II-defined Lynch-related cancer cases with family history but is rare in other cancers: a summary of 1000 analyses

Table 3 Clinical and demographic factors analyzed for the association with MSI-H cancer (n = 1000)

	n	MSI positive		Univariate analysis		Multivariate analysis
	n	n	%	Odd’s ratio (95% confidence interval)	P value	Odd’s ratio (95% confidence interval)	P value
Age
≤ 50y.o.	179	27	15.1%	1.88 (1.17–3.01)	0.01
> 50y.o	821	71	8.6%
Gender
Male	519	42	8.1%	0.67 (0.44–1.02)	0.07
Female	481	56	11.6%
HBsAg and HCVAb
Both (−)	950	92	9.7%	0.72 (0.26–2.02)	0.54
Either (+)	31	4	12.9%
Smoker
Yes	576	58	10.1%	1.10 (0.71–1.64)	0.83
No	424	40	9.4%
Drinker
Yes	486	43	8.8%	0.81 (0.53–1.23)	0.34
No	514	55	10.7%
Cancer type
LS(AII)-related cancers§	556	87	15.6%	7.30 (3.88–13.72)	< 0.0001	9.56 (4.09–28.05)	< 0.0001
Others	444	11	2.5%
LS(rB)-related cancers#	844	92	10.9%	3.06 (1.34–6.95)	0.005
Others	156	6	3.8%
Purpose of MSI test
Genetic counseling	222	74	33.3%	15.71 (9.63–25.62)	< 0.0001	15.01 (8.91–26.17)	< 0.0001
Companion diagnostics	778	24	3.1%

MSI-H high frequency of microsatellite instability, AII Amsterdam II criteria, rB revised Bethesda guidelines.LS(AII)-related cancers consist of colorectal cancer, endometrial cancer, renal pelvic and ureteral cancers, and small intestine cancer, and LS(rB)-related cancers include additional tumors; gastric cancer, ovarian cancer, pancreatic cancer, biliary tract cancer, brain tumor, and two cutaneous neoplasms (sebaceous adenoma and keratoacanthoma)

ISSN: 1471-2407