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Table 1 Demographic characteristics of included studies

From: Exercise-based dysphagia rehabilitation for adults with oesophageal cancer: a systematic review

Authors, year

Study Design

Study Setting

N

Age

Sex

Co-morbidities

Stage of cancer

Location of cancer

Type of cancer treatment

Complications post-surgery

Dysphagia Assessment for Outcomes

Okumura et al., 2016 [37]

Case Control Study (CCS)

Toyoma University Hospital, Japan

26

CG; Mean 65.9 +/− 9.7 yrs.

TG: 68+/−5.1 yrs.

CG: 13/1 M:F

TG: 12 M

NI

TNM Classification (JES) -I/II CG: 11 (78.6%) TG: 5 (41.7%) -III/IV CG: 3 (21.4%) TG: 7 (58.3%) TNM Classification (UICC) - I/II CG:12 (85.7%) TG: 8 (66.7%) -III/IV CG: 2 (14.3%) TG: 4 (33.3%)

Thoracic

“Oesophagectomy” 5 participants: neoadjuvant chemotherapy

CG:

RLNP (n = 4)

AP (n = 3)

AL (n = 2)

TG:

RLNP(n = 2),

AP (n = 3)

AL (n = 2)

Non-validated:

1. Functional Outcomes Assessment Measure of Swallowing (FOAMS) Scale.

2 Measured relevant biomechanical positions and volumes on x-axis and y-axis plots from VFSS images

Tsubosa et al., 2005 [69]

Case Series (CS)

Shizuoka Cancer Hospital Rehabilitation Dept., Japan

9

Mean 57.8 +/− 9 yrs.

9 M

Cases 1: Hx of RTC; 2: old age; 3: Hx of stroke and abnormal shape of epiglottis; and 4: abnormal shape of epiglottis. The remaining 5 cases had no relevant co-morbidities that may affect swallowing

NI

Thoracic

“Oesophagectomy”

RLNP (n = 5. 1 of which was bilateral resulting in severe AP)

Non-validated:

VFSS rating tool suggested by Logemann, 1998

Takatsu et al., 2020 [70]

Retrospective case control study

Aichi Cancer Centre Hospital, Japan

276

CG; median 68 (IQR 64–74)

TG; 69 (IQR 62–73)

CG: 91/18 M:F

TG: 142/25 M:F

NI

TNM Classification (UICC)

-I/II CG: 49 (45%)

TG: 56 (45%)

-III/IV CG: 60 (55%)

TG: 91 (55%)

Thoracic

CG: Neoadjuvant therapies: 87 (80%)

Thoracoscopic oesophagectomy

Open Oesophagectomy

Cervical anastomosis

TG: Neoadjuvant therapies: 133 (80%)

Thoracoscopic oesophagectomy

Open oesophagectomy

Cervical anastomosis

CG:

RLNP 22 (20%)

Pneumonia 25 (23%)

AL: 8 (7%)

TG:

RLNP 34 (20%)

Pneumonia 39 (23%)

AL 22 (13%)

1. Start of oral intake

2. Length of oral intake rehabilitation

3. Length of postoperative stay

  1. Key: Std Dev Standard Deviation, NI No Information provided, RLNP Recurrent Laryngeal Nerve Palsy, AP Aspiration Pneumonia, VFSS Videofluoroscopy, CG control group, TG treatment group, JES Japan Esophageal Society, UICC Union for International Cancer Control, Yrs years, AL Anastomatic Leak, Hx history, RTC radiotherapy for tongue cancer