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Table 1 Patients’ clinicopathological parameters and correlation with TAMs

From: Secretion of BMP-2 by tumor-associated macrophages (TAM) promotes microcalcifications in breast cancer

Parameters

High CD68 (%)

N = 123

LOW CD68 (%)

N = 149

χ2 value

P value

High CD163 (%)

N = 125

LOW CD163 (%)

N = 147

χ2 value

P value

Age

  

2.469

0.116

  

0.773

0.379

  ≤ 45

43 (35.0)

39 (26.2)

  

41 (32.8)

41 (27.9)

  

 >45

80 (65.0)

110 (73.8)

  

84 (67.2)

106 (72.1)

  

Tumor size

  

0.925

0.819

  

2.522

0.471

 T1

38 (30.9)

52 (34.9)

  

36 (28.8)

54 (36.7)

  

 T2

76 (61.8)

89 (59.7)

  

80 (64)

85 (57.8)

  

 T3

6 (4.9)

6 (4.0)

  

7 (5.6)

5 (3.4)

  

 T4

3 (2.4)

2 (1.3)

  

2 (1.6)

3 (2.0)

  

Axillary metastasis

  

1.544

0.672

  

1.783

0.619

 N0

58 (47.2)

79 (53.0)

  

62 (49.6)

75 (51.0)

  

 N1

33 (26.9)

35 (23.5)

  

28 (22.4)

40 (27.2)

  

 N2

20 (16.3)

25 (16.8)

  

24 (19.2)

21 (14.3)

  

 N3

12 (9.8)

10 (6.7)

  

11 (8.8)

11 (7.5)

  

Hormonal receptor

  

2.177

0.140

  

3.622

0.057

 Positive

88 (71.5)

94 (63.1)

  

91 (72.8)

91 (61.9)

  

 Negative

35 (28.5)

55 (36.9)

  

34 (27.2)

56 (38.1)

  

Her-2

  

2.420

0.120

  

3.007

0.083

 Positive

30 (24.4)

25 (16.8)

  

31 (24.8)

24 (16.3)

  

 Negative

93 (75.6)

124 (83.2)

  

94 (75.2)

123 (83.7)

  

Microcalcifications

  

9.141

0.002

  

28.060

0.000

 With microcalcifications

46 (37.4)

31 (20.8)

  

55 (44.0)

22 (15.0)

  

 Without microcalcifications

77 (62.6)

118 (79.2)

  

70 (56.0)

125 (85.0)

  

Follow up (month)

116

115

  

115

115

  

Recurrence

24

20

  

29

15

  
  1. T docetaxel, P platinum, E epirubicin, C cyclophosphamide, F 5-fluorouracil