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Table 1 Patients’ clinicopathological parameters and correlation with TAMs

From: Secretion of BMP-2 by tumor-associated macrophages (TAM) promotes microcalcifications in breast cancer

Parameters High CD68 (%)
N = 123
LOW CD68 (%)
N = 149
χ2 value P value High CD163 (%)
N = 125
LOW CD163 (%)
N = 147
χ2 value P value
Age    2.469 0.116    0.773 0.379
  ≤ 45 43 (35.0) 39 (26.2)    41 (32.8) 41 (27.9)   
 >45 80 (65.0) 110 (73.8)    84 (67.2) 106 (72.1)   
Tumor size    0.925 0.819    2.522 0.471
 T1 38 (30.9) 52 (34.9)    36 (28.8) 54 (36.7)   
 T2 76 (61.8) 89 (59.7)    80 (64) 85 (57.8)   
 T3 6 (4.9) 6 (4.0)    7 (5.6) 5 (3.4)   
 T4 3 (2.4) 2 (1.3)    2 (1.6) 3 (2.0)   
Axillary metastasis    1.544 0.672    1.783 0.619
 N0 58 (47.2) 79 (53.0)    62 (49.6) 75 (51.0)   
 N1 33 (26.9) 35 (23.5)    28 (22.4) 40 (27.2)   
 N2 20 (16.3) 25 (16.8)    24 (19.2) 21 (14.3)   
 N3 12 (9.8) 10 (6.7)    11 (8.8) 11 (7.5)   
Hormonal receptor    2.177 0.140    3.622 0.057
 Positive 88 (71.5) 94 (63.1)    91 (72.8) 91 (61.9)   
 Negative 35 (28.5) 55 (36.9)    34 (27.2) 56 (38.1)   
Her-2    2.420 0.120    3.007 0.083
 Positive 30 (24.4) 25 (16.8)    31 (24.8) 24 (16.3)   
 Negative 93 (75.6) 124 (83.2)    94 (75.2) 123 (83.7)   
Microcalcifications    9.141 0.002    28.060 0.000
 With microcalcifications 46 (37.4) 31 (20.8)    55 (44.0) 22 (15.0)   
 Without microcalcifications 77 (62.6) 118 (79.2)    70 (56.0) 125 (85.0)   
Follow up (month) 116 115    115 115   
Recurrence 24 20    29 15   
  1. T docetaxel, P platinum, E epirubicin, C cyclophosphamide, F 5-fluorouracil