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Table 3 Univariate and multivariate analyses of potential prognostic factors for OS

From: A novel prognostic index for sporadic Burkitt lymphoma in adult patients: a real-word multicenter study

  Univariate analysis Multivariate analysis
Characteristics HR (95% CI) P HR (95% CI) P
Age
  < 60     
  ≥ 60 0.754(0.35–1.626) 0.472 1.012(0.407–2.519) 0.979
Gender
 Male     
 Female 0.502(0.24–1.046) 0.066   
ECOG score
  < 2     
  ≥ 2 4.457(1.973–10.069) < 0.001 0.323(0.101–1.031) 0.056
Ann Arbor stages
 I–II     
 III–IV 2.744 (1.316–5.723) 0.007 1.287(0.362–4.572) 0.696
B symptoms 1.155(0.593–2.252) 0.672 1.409(0.577–3.438) 0.452
Risk stratification
 Low     
 High 5.214(1.863–14.594) 0.002 0.113(0.024–0.519) 0.005
Bone marrow involved 2.256 (1.158–4.395) 0.017 2.136(0.799–5.71) 0.13
CNS involved 0.469(0.184–1.194) 0.112   
Lymph-node involvement 1.081(0.594–1.966) 0.799   
Extranodal involvement sites
  < 2     
  ≥ 2 2.143(1.144–4.014) 0.017 0.841(0.351–2.016) 0.698
EBERs 0.147(0.035–0.61) 0.008 9.825(1.31–73.703) 0.026
ALB < 40 mg/L 0.387(0.208–0.718) 0.003 2.251(1.034–4.902) 0.041
CRP ≥ 10 mg/L 2.612(1.369–4.982) 0.004 1.124(0.494–2.557) 0.781
LDH ≥ 334 U/L 5.361(2.747–10.462) < 0.001 0.199(0.081–0.488) < 0.001
d-NLR ≥ 1.6 2.71(1.487–4.939) 0.001 0.501(0.246–1.019) 0.056
PLT < 254 × 109/L 0.348(0.171–0.706) 0.003 2.261(1.047–4.886) 0.038
IPI score ≥ 2 2.376(1.171–4.822) 0.017 4.195(1.34–13.139) 0.014
Radiation therapy 0.928(0.391–2.203) 0.866   
ASCT 0.393(0.054–2.857) 0.356   
CNS prophylaxis 0.619(0.261–1.467) 0.276   
Abdominal lesions 1.152(0.612–2.166) 0.661