Table 3 Univariate and multivariate analyses of potential prognostic factors for OS
| Â | Univariate analysis | Multivariate analysis | ||
|---|---|---|---|---|
Characteristics | HR (95% CI) | P | HR (95% CI) | P |
Age | ||||
  < 60 |  |  |  |  |
  ≥ 60 | 0.754(0.35–1.626) | 0.472 | 1.012(0.407–2.519) | 0.979 |
Gender | ||||
 Male |  |  |  |  |
 Female | 0.502(0.24–1.046) | 0.066 |  |  |
ECOG score | ||||
  < 2 |  |  |  |  |
  ≥ 2 | 4.457(1.973–10.069) | < 0.001 | 0.323(0.101–1.031) | 0.056 |
Ann Arbor stages | ||||
 I–II |  |  |  |  |
 III–IV | 2.744 (1.316–5.723) | 0.007 | 1.287(0.362–4.572) | 0.696 |
B symptoms | 1.155(0.593–2.252) | 0.672 | 1.409(0.577–3.438) | 0.452 |
Risk stratification | ||||
 Low |  |  |  |  |
 High | 5.214(1.863–14.594) | 0.002 | 0.113(0.024–0.519) | 0.005 |
Bone marrow involved | 2.256 (1.158–4.395) | 0.017 | 2.136(0.799–5.71) | 0.13 |
CNS involved | 0.469(0.184–1.194) | 0.112 |  |  |
Lymph-node involvement | 1.081(0.594–1.966) | 0.799 |  |  |
Extranodal involvement sites | ||||
  < 2 |  |  |  |  |
  ≥ 2 | 2.143(1.144–4.014) | 0.017 | 0.841(0.351–2.016) | 0.698 |
EBERs | 0.147(0.035–0.61) | 0.008 | 9.825(1.31–73.703) | 0.026 |
 ALB < 40 mg/L | 0.387(0.208–0.718) | 0.003 | 2.251(1.034–4.902) | 0.041 |
 CRP ≥ 10 mg/L | 2.612(1.369–4.982) | 0.004 | 1.124(0.494–2.557) | 0.781 |
 LDH ≥ 334 U/L | 5.361(2.747–10.462) | < 0.001 | 0.199(0.081–0.488) | < 0.001 |
 d-NLR ≥ 1.6 | 2.71(1.487–4.939) | 0.001 | 0.501(0.246–1.019) | 0.056 |
 PLT < 254 × 109/L | 0.348(0.171–0.706) | 0.003 | 2.261(1.047–4.886) | 0.038 |
 IPI score ≥ 2 | 2.376(1.171–4.822) | 0.017 | 4.195(1.34–13.139) | 0.014 |
Radiation therapy | 0.928(0.391–2.203) | 0.866 |  |  |
ASCT | 0.393(0.054–2.857) | 0.356 |  |  |
CNS prophylaxis | 0.619(0.261–1.467) | 0.276 |  |  |
Abdominal lesions | 1.152(0.612–2.166) | 0.661 |  |  |