Table 2 Univariate and Multivariate Cox proportional hazards models to predict survival in patients with unresectable pancreatic cancer

Age

<60

reference

60–70

0.99

0.74 – 1.35

0.998

1.07

0.77 – 1.50

0.674

>70

0.99

0.70 – 1.39

0.936

1.08

0.73 – 1.59

0.710

Sex

F

reference

M

0.92

0.71 – 1.19

0.517

0.96

0.71 – 1.28

0.766

ECOG PS

0

reference

1

1.54

1.16 – 2.04

0.003

1.43

1.03 – 1.93

0.033

2 or more

2.22

1.30 – 3.79

0.003

2.52

1.34 – 4.71

0.004

Body mass index

<22

reference

≥22

1.01

0.77 – 1.30

0.969

0.98

0.73 – 1.31

0.880

Tumor resection

no

reference

yes

0.73

0.50 – 1.07

0.103

0.71

0.45 – 1.12

0.142

Head

reference

Body

1.04

0.78 – 1.39

0.800

0.89

0.63 – 1.25

0.496

Tail

1.14

0.81 – 1.61

0.461

0.72

0.47 – 1.10

0.133

Tumor size

<20

reference

20 – 40

0.99

0.67 – 1.47

0.979

0.94

0.60 – 1.47

0.775

>40

1.39

0.91 – 2.11

0.125

0.88

0.54 – 1.43

0.605

Histology

Adenocarcinoma

reference

Others

1.09

0.75 – 1.56

0.656

1.26

0.83 – 1.90

0.280

Liver metastasis

No

reference

Yes

2.08

1.61 – 2.69

< 0.001

1.85

1.26 – 2.73

0.002

Peritoneal metastasis

No

reference

Yes

0.95

0.68 – 1.31

0.742

0.91

0.57 – 1.44

0.674

Lung metastasis

No

reference

Yes

1.39

0.95 – 1.31

0.09

1.40

0.86 – 2.29

0.176

Number of metastasis

0 or 1

reference

2 or more

1.59

1.21 – 2.09

< 0.001

1.17

0.80 – 1.71

0.422

Ascites

No

reference

Yes

1.52

1.12 – 2.05

0.007

1.37

0.93 – 2.00

0.112

Albumin (g/dL), n (%)

>4

reference

3 – 4

0.82

0.54 – 1.24

0.349

1.45

0.88 – 2.37

0.144

<3

0.56

0.36 – 0.88

0.012

1.29

0.72 – 2.27

0.399

LDH (U/L), n (%)

<240

reference

240 – 360

1.91

1.32 – 2.77

< 0.001

1.51

0.97 – 2.33

0.065

>360

2.90

1.36 – 6.19

0.006

2.88

1.35 – 6.82

0.007

CRP (mg/dL), n (%)

<0.3

reference

0.3–3.0

1.45

1.09 – 1.92

0.010

1.12

0.81 – 1.55

0.503

>3.0

3.04

2.09 – 4.43

< 0.001

2.04

1.23 – 3.36

0.005

CA19–9 (U/mL), n (%)

<37

reference

37 – 370

1.24

0.84 – 1.84

0.285

1.18

0.77 – 1.80

0.441

>370

1.91

1.36 – 2.68

< 0.001

1.45

1.01 – 2.07

0.043

III

reference

IV

1.73

1.24 – 2.44

0.001

1.14

0.70 – 1.86

0.606

First line regimen, n (%)

FFX

reference

GnP

0.86

0.66 – 1.11

0.249

0.72 – 1.36

0.942