Dose level (cohort) | Daily dose of PHI-101 (once daily) | Escalation increment from the previous dose | ||
---|---|---|---|---|
-1 | 20 mg | 1 tab. | - 20 mg | - 50% |
1 (starting dose) | 40 mg | 2 tab. | - | - |
2 | 80 mg | 4 tab. | 40 mg | 100% |
3 | 120 mg | 6 tab. | 40 mg | 50% |
4 | 160 mg | 8 tab. | 40 mg | 33% |
5 | 200 mg | 10 tab. | 40 mg | 25% |
6 (maximum planned dose) | 240 mg | 12 tab. | 40 mg | 20% |