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Table 2 Various features in the group of patients studied with respect to CRC outcome

From: Colorectal Cancer in North-Eastern Iran: a retrospective, comparative study of early-onset and late-onset cases based on data from the Iranian hereditary colorectal cancer registry

CRC outcome
Variable
Recovered = 234
Number (%)
Deceased = 59
Number (%)
Total = 293
Number (%)
P-value
Continuous age - mean (SD) 53.58 (14.11) 59.25 (16.88) 54.72 (14.86) 0.009
Age range (years)
 20–29 8 (3.4) 3 (5.1) 11 (3.8)  
 30–39 31 (13.2) 6 (10.2) 37 (12.6)  
 40–49 55 (23.5) 8 (13.6) 63 (21.5) 0.03d
 50–59 57 (24.4) 11 (18.6) 68 (23.2)  
 60–69 40 (17.1) 10 (16.9) 50 (17.1)  
 70–79 35 (15.0) 13 (22.0) 48 (16.4)  
  ≥ 80 8 (3.4) 8 (13.6) 16 (5.5)  
Gender
 Female 156 (49.0) 29 (49.0) 185 (49.0) 0.9c
 Male 159 (51.0) 30 (51.0) 189 (51.0)  
Amsterdam II
 Criteria absent 196 (95.1) 53 (96.3) 249 (95.0) 0.7c
 Criteria present 10 (4.9) 2 (3.7) 12 (5.0)  
Tumour location
 Proximal 30 (14.2) 6 (10.9) 36 (13.5) 0.2c
 Distal 126 (59.4) 28 (50.9) 154 (57.7)  
 Rectum 56 (26.4) 21 (38.2) 77 (28.8)  
Mismatch repair status
 Proficient 143 (92.0) 31 (77.5) 174 (89.0) 0.02c
 Deficient 13 (8.0) 9 (22.5) 22 (11.0)  
At high risk for LSa
 No 145 (93.0) 32 (80.0) 177 (90.0) 0.03c
 Yes 11 (7.0) 8 (20.0) 19 (10.0)  
MLH1
 pMMR 147 (94.0) 34 (85.0) 181 (92.0) 0.05c
 dMMR 9 (6.0) 6 (15.0) 15 (8.0)  
PMS2
 pMMR 145 (94.0) 33 (82.0) 178 (91.0) 0.02c
 dMMR 10 (6.0) 7 (18.0) 17 (9.0)  
MSH2
 pMMR 152 (98.0) 38 (95.0) 190 (97.0) 0.27c
 dMMR 3 (2.0) 2 (5.0) 5 (3.0)  
MSH6
 pMMR 153 (98.0) 38 (95.0) 191 (97.0) 0.27c
 dMMR 3 (2.0) 2 (5.0) 5 (3.0)  
  1. CRC colorectal cancer, MMR mismatch repair, pMMR mismatch repair proficiency, dMMR mismatch repair-deficiency, LS Lynch syndrome
  2. aDefined as the CRC cases with absent MMR proteins and normal BRAF status (if MLH1 was absent)
  3. c Analysis by Fisher’s exact test
  4. d Analysis by Chi-square test