Table 6 Subgroup analysis of non-hematological toxicity
Any grades of Coagulation toxicity | ||||||
| Â | Â | Â | APTT prolonged | Fibrinogen decreased | ||
Pathological type | leukemia | rate | 50% (3–97%) | P > 0.05 | 12% (7–41%) | P > 0.05 |
N | 98 | 118 | ||||
MM | rate | 59% (19–94%) | 16% (1–41%) | |||
N | 123 | 103 | ||||
Any grades of Hepatic toxicity | ||||||
| Â | Â | Â | AST increased | ALT increased | ||
Pathological type | leukemia | rate | 25% (18–32%) | P > 0.05 | 34% (24–44%) | P > 0.05 |
N | 154 | 93 | ||||
lymphoma | rate | 24% (16–34%) | 21% (15–27%) | |||
N | 249 | 249 | ||||
MM | rate | 44% (14–77%) | 25% (19–32%) | |||
N | 120 | 188 | ||||
≥3 grade of Hepatic toxicity | ||||||
| Â | Â | Â | AST increased | ALT increased | ||
Pathological type | leukemia | rate | 7% (3–12%) | P = 0.0016 | 4% (1–7%) | P > 0.05 |
N | 236 | 250 | ||||
lymphoma | rate | 1% (0–4%) | 1% (0–3%) | |||
N | 249 | 249 | ||||
MM | rate | 16% (9–25%) | 1% (0–4%) | |||
N | 132 | 200 | ||||