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Table 2 Basic characteristics of the included patients

From: Adverse effects in hematologic malignancies treated with chimeric antigen receptor (CAR) T cell therapy: a systematic review and Meta-analysis

Name

Disease

Sample

Sex

(male%)

Age

[median(range)]

Prior therapy lines

HSCT%

Abramson, J. S

lymphoma

269

65%

63(54–70)

≥3 lines: 51%

35%

Zhiling Yan

MM

21

48%

58(49.5–61)

mean lines: 6

14%

Ali, S. A

MM

12

  

median lines: 7

100%

Cohen, A. D

MM

25

68%

58(44–75)

median(range) lines: 7(3–13)

92%

Curran, K. J

ALL

25

 

13.5(1–22.5)

Not found

20%

Enblad, Gunilla

lymphoma+ALL

15

47%

61(24–71)

mean lines: 1.73

40%

Fry, T. J

B-ALL

21

62%

19(7–30)

Not found

90%

Gardner, R. A

B-ALL

43

44%

12.3(1.3–25.4)

Not found

62%

Geyer, M. B.

CLL

8

100%

58(45–70)

Not found

 

Geyer, M. B

CLL + NHL

20

70%

63(43–75)

median(range) lines:

4(1–11)

0

Goto, H

DLBCL

9

56%

61(32–73)

mean lines; 3

44.40%

Fried, S.

ALL+NHL

35

71%

27(3.5–55)

Not found

37%

Lee, D. W

ALL+DLBCL

19

67%

1 to 30

mean lines: 2

38%

Locke, F. L

lymphoma

108

68%

Phase 1:

59 (IQR34–69);Phase 2:

58 (IQR51–64)

median lines: 3

23%

Maude, S. L

ALL

75

57%

11(3–23)

median(range) lines:

3(1–8)

61%

Xu, J

MM

17

65%

55(40–73)

median(range) lines:

5(3–11)

47%

Schuster, S. J

DLBCL

111

65%

56 (22–76)

≥3 lines: 52%

49%

Raje, N

MM

33

64%

60(37–75)

median(range) lines: 7(3–23)

97%

Schuster, S. J

FCL + DLBCL

28

64%

57.5(25–77)

median(range) lines: 4.5 (1–10)

39%

Wang, Na

ALL

51

63%

27 (9–62)

Not found

24%

Wang, Na

NHL

38

58%

47 (17–71)

Not found

15.80%

Zhao, W. H

MM

57

60%

54 (27–72)

median(range) lines: 3 (1–9)

18%

Wang, M

MM

68

84%

65 (38–79)

≥3lines 81%;

median(range) lines: 3 (1–5)

43%

Sang, W

DLBCL

21

62%

55 (23–72)

median(range) lines: 3(1–6)

5%

Wayne AS,

ALL

24

63%

13(3–20)

≥3 lines: 42%

25%

Ghorashian, S

ALL

14

93%

9.24 (1.35–19.28)

median(range) lines: 4(2–7)

71%

Wang, Jia

ALL

23

61%

42(10–67)

median(range) lines: 2(2–3)

22%

Bao, F.

ALL+NHL

10

40%

33.5(25–69)

Not found

 

Hu, Jianda

DLBCL

8

 

52(27–70)

Not found

 

Jiang, Songfu

MM

16

 

55 (39–67)

median(range) lines:

4(2–10)

56%

Wierda, William G

ALL

35

51%

40(18–69)

≥3 lines: 60%

 

Yan, Lingzhi

MM

28

82%

57.5 (42–69)

mean(range) lines: 3(2–8)

 

Amrolia, Persis J.

ALL

8

 

7.5(4–16)

Not found

63%

Ardeshna, Kirit

DLBCL

11

 

49

median lines: 3

27%

Strati, Paolo

lymphoma

31

74%

52(23–76)

>3lines 45%;

median(range) lines: 3(1–11)

35%

Yan, Zi-Xun

NHL

10

80%

47(32–59)

≥3lines: 100%

 

Ying, Zhitaob

NHL

3

67%

<65

mean lines: 9.7

0

Ying, Zhitaob

NHL

3

100%

<65

mean lines: 8

0

Topp, M. S.

lymphoma

21

67%

63 (36–73)

≥2lines: 76%

10%

An, F

ALL

47

49%

22(3–72)

<10lines: 59.6%

19.10%

Dourthe, M. E

ALL

41

 

18.2(1–29.2)

Not found

63%

Mailankody, S

MM

51

 

61(33–77)

median(range) lines: 6 (3–18)

 

Popat, R

MM

11

 

61 (45–69)

median(range) lines: 5(3–6)

73%

Ramos, C. A

HL

42

67%

35(17–69)

median(range) lines: 7(2–23)

100%

Sesques, Pc

DLBCL

33

72%

62 (28–75)

≥4 lines: 64%

30%

Sesques, Pc

DLBCL

28

57%

59 (27–72)

≥4 lines: 79%

29%

Shah, N. N

lymphoma

22

86%

57 (38–72)

Not found

50%

Tong, C

NHL

28

39%

 

≥3 lines: 79%

 

Usmani, S. Z

MM

29

  

median(range) lines: 5(3–18)

 

Wang, Y

ALL

21

52%

13 (3–69)

median(range) lines: 4(1–7)

9.52%

Zhou, X

NHL + DLBCL

21

62%

31 to 77

≥4 lines: 38%

 

Ramos, Carlos A

NHL

16

 

67(17–73)

Not found

31%

Zhang, W. Y

NHL

11

 

≥18

Not found

9%

Jain, T

NHL + ALL+MM

83

67%

58(19–85)

Not found

37%

Jacobson, Caron

iNHL

146

57%

61(34–79)

median(range) lines: 3(1–10)

 
  1. a The two are from the same article. The former data was focusing on the patients with ALL (acute lymphocytic leukemia) and the latter data was focusing on the patients with NHL (Non-Hodgkin Lymphoma)
  2. b The two are from the same article. The co-stimulatory molecule of the former dataset is CD28, and that of the latter dataset is 41BB
  3. c The two are from the same article. Axicabtagene ciloleucel is used in the former dataset and tisagenlecleucel is used in the latter dataset