Table 3 Clinical and Histological Characteristics for those with and without somatic BRCA1 or BRCA2 PSVs
Somatic BRCA1 or BCRA2 | ||||
|---|---|---|---|---|
No (N = 72) | Yes (N = 15) | |||
n | % | n | % | |
Age at diagnosis | ||||
Mean ± SD | 51.90 | 12.10 | 55.73 | 9.95 |
Median (Q1-Q3) | 51.50 | 44.50-60.0 | 56.00 | 47.0-64.0 |
Family History | ||||
Yes | 7 | 9.7% | 2 | 13.3% |
No | 65 | 90.3% | 13 | 86.7% |
Laterality | ||||
Bilateral | 56 | 77.8% | 10 | 66.7% |
Unilateral | 16 | 22.2% | 5 | 33.3% |
Allele | ||||
Not Wild | 17 | 23.6% | 12 | 80.0% |
Wild | 55 | 76.4% | 3 | 20.0% |
Stage at Diagnosis | ||||
Unknown | 4 | 5.6% | 0 | 0.0% |
0 | 1 | 1.4% | 1 | 6.7% |
I | 13 | 18.1% | 3 | 20.0% |
IIA | 4 | 5.6% | 2 | 13.3% |
IIB | 4 | 5.6% | 1 | 6.7% |
IIIA | 6 | 8.3% | 1 | 6.7% |
IIIC | 26 | 36.1% | 5 | 33.3% |
IV | 14 | 19.4% | 2 | 13.3% |
Tumor stage | ||||
Unknown | 4 | 5.6% | 0 | 0.0% |
Tis | 1 | 1.4% | 0 | 0.0% |
T1a | 4 | 5.6% | 0 | 0.0% |
T1b | 1 | 1.4% | 0 | 0.0% |
T1c | 9 | 12.5% | 3 | 20.0% |
T2a | 4 | 5.6% | 1 | 6.7% |
T2b | 5 | 6.9% | 0 | 0.0% |
T2c | 1 | 1.4% | 1 | 6.7% |
T3a | 11 | 15.3% | 4 | 26.7% |
T3b | 3 | 4.2% | 1 | 6.7% |
T3c | 24 | 33.3% | 4 | 26.7% |
Tx | 5 | 6.9% | 1 | 6.7% |
Node stage | ||||
Unknown | 4 | 5.6% | 0 | 0.0% |
N0 | 17 | 23.6% | 2 | 13.3% |
N1 | 8 | 11.1% | 4 | 26.7% |
Nx | 43 | 59.7% | 9 | 60.0% |
Metastatic stage | ||||
Unknown | 4 | 5.6% | 0 | 0.0% |
M0 | 25 | 34.7% | 5 | 33.3% |
M1 | 6 | 8.3% | 2 | 13.3% |
Mx | 37 | 51.4% | 8 | 53.3% |
FIGO classification | ||||
IA | 3 | 4.2% | 0 | 0.0% |
IB | 0 | 0.0% | 0 | 0.0% |
IC | 11 | 15.3% | 3 | 20.0% |
IIA | 4 | 5.6% | 2 | 13.3% |
IIB | 3 | 4.2% | 1 | 6.7% |
IIC | 1 | 1.4% | 0 | 0.0% |
IIIA | 3 | 4.2% | 0 | 0.0% |
IIIB | 3 | 4.2% | 1 | 6.7% |
IIIC | 24 | 33.3% | 4 | 26.7% |
IV | 5 | 6.9% | 3 | 20.0% |
Unknown | 15 | 20.8% | 1 | 6.7% |
ECOG Performance status | ||||
0 | 47 | 65.3% | 9 | 60.0% |
1 | 17 | 23.6% | 5 | 33.3% |
2 | 5 | 6.9% | 1 | 6.7% |
3 | 3 | 4.2% | 0 | 0.0% |
Tumor type | ||||
High grade serous carcinoma | 29 | 38.7% | 10 | 66.7% |
Low grade serous carcinoma | 3 | 4.0% | 0 | 0.0% |
Serous carcinoma (Not classified) | 20 | 26.7% | 2 | 13.3% |
Endometrioid carcinoma | 5 | 6.7% | 1 | 6.7% |
Adenosarcoma | 5 | 6.7% | 0 | 0.0% |
Mixed carcinoma | 4 | 5.3% | 0 | 0.0% |
Clear cell carcinoma | 2 | 2.7% | 0 | 0.0% |
Carcinosarcoma | 0 | 0.0% | 1 | 6.7% |
Mucinous carcinoma | 1 | 1.3% | 0 | 0.0% |
Müllerian mixed tumor | 1 | 1.3% | 0 | 0.0% |
Serous borderline tumor, micropapillary variant | 1 | 1.3% | 0 | 0.0% |
Unclassified | 1 | 1.3% | 1 | 6.7% |