Table 2 Univariate and multivariate analyses for overall survival in CRC

 Female

1

 Male

1.23 (0.98–1.50)

0.076

 I

1

1

 II

1.70 (0.94–3.10)

0.082

1.45 (0.79–2.66)

 III

2.34 (1.28–4.25)

0.006

1.74 (0.95–3.21)

 IV

8.26 (4.50–15.18)

< 0.001

6.07 (3.25–11.35)

 Left colon, rectum

1

 Right colon

1.13 (0.90–1.42)

0.304

 MSI

1

 MSS

1.11 (0.78–1.58)

0.566

 CMS1

1

1

 CMS2

0.97 (0.67–1.38)

0.848

0.94 (0.63–1.39)

 CMS3

0.70 (0.42–1.16)

0.171

0.67 (0.37–1.17)

 CMS4

1.45 (1.00–2.11)

0.049

1.10 (0.74–1.64)

 Indeterminate

1.55 (0.98–2.46)

0.064

1.41 (0.87–2.29)

 Wild-type

1

1

 Mutated

1.27 (1.01–1.61)

0.043

1.29 (1.00–1.66)

 Wild-type

1

 Mutated

1.23 (0.85–1.79)

0.28

Wild-type

1

Mutated

1.20 (0.92–1.57)

 Low

1

 High

1.14 (0.83–1.57)

 Group I + II

1

1

 Group III

1.68 (1.30–2.17)

< 0.001

1.41 (1.05–1.90)

 Group IV

1.20 (0.90–1.60)

0.223

1.06 (0.77–1.48)