| |
Univariate analysis
|
Multivariate analysis
|
|---|
| |
HR (95% CI)
|
p
|
HR (95% CI)
|
p
|
|---|
|
Gender
|
|
Female
|
1
| | | |
|
Male
|
1.23 (0.98–1.50)
|
0.076
| | |
|
Stage
|
|
I
|
1
| |
1
| |
|
II
|
1.70 (0.94–3.10)
|
0.082
|
1.45 (0.79–2.66)
|
0.225
|
|
III
|
2.34 (1.28–4.25)
|
0.006
|
1.74 (0.95–3.21)
|
0.074
|
|
IV
|
8.26 (4.50–15.18)
|
< 0.001
|
6.07 (3.25–11.35)
|
< 0.001
|
|
Location
|
|
Left colon, rectum
|
1
| | | |
|
Right colon
|
1.13 (0.90–1.42)
|
0.304
| | |
|
Microsatellite
|
|
MSI
|
1
| | | |
|
MSS
|
1.11 (0.78–1.58)
|
0.566
| | |
|
CMS
|
|
CMS1
|
1
| |
1
| |
|
CMS2
|
0.97 (0.67–1.38)
|
0.848
|
0.94 (0.63–1.39)
|
0.743
|
|
CMS3
|
0.70 (0.42–1.16)
|
0.171
|
0.67 (0.37–1.17)
|
0.160
|
|
CMS4
|
1.45 (1.00–2.11)
|
0.049
|
1.10 (0.74–1.64)
|
0.625
|
|
Indeterminate
|
1.55 (0.98–2.46)
|
0.064
|
1.41 (0.87–2.29)
|
0.159
|
|
KRAS status
|
|
Wild-type
|
1
| |
1
| |
|
Mutated
|
1.27 (1.01–1.61)
|
0.043
|
1.29 (1.00–1.66)
|
0.048
|
|
BRAF status
|
|
Wild-type
|
1
| | | |
|
Mutated
|
1.23 (0.85–1.79)
|
0.28
| | |
|
TP53 status
|
|
Wild-type
|
1
| | | |
|
Mutated
|
1.20 (0.92–1.57)
| | | |
|
CIMP
|
|
Low
|
1
| | | |
|
High
|
1.14 (0.83–1.57)
| | | |
|
Group
|
|
Group I + II
|
1
| |
1
| |
|
Group III
|
1.68 (1.30–2.17)
|
< 0.001
|
1.41 (1.05–1.90)
|
0.023
|
|
Group IV
|
1.20 (0.90–1.60)
|
0.223
|
1.06 (0.77–1.48)
|
0.709
|
- GSE39582 and TCGA samples of CRC were pooled for this analysis
- Abbreviations: HR hazard ratio
