Fig. 1

Peroxisome-Low CRC patients had poor clinical outcomes despite high immune infiltrates. a, b Kaplan–Meier analysis of OS in TCGA colorectal cancer cohort (n = 593) and NCBI GEO-GSE39582 cohort (n = 556). P values were calculated by the log-rank test. c The volcano plot shows the enrichment analysis using hallmark gene sets in TCGA cohort. The red gene sets were enriched in the Per-High group, whereas the blue gene sets were enriched in the Per-Low group. d Correlation between the peroxisome score versus immune score, stromal score, and tumor purity in TCGA cohort. e Violin plots of the immune score, stromal score, and tumor purity from ESTIMATE of Per-High and Per-Low groups in TCGA cohort. f Violin plot of total immune infiltrates (sum of absolute scores across 22 immune cell types) among the CRC subgroups in TCGA. g Correlation between peroxisome scores and total immune infiltrates of patients in TCGA cohort. For violin plots, p values in group comparisons with Mann–Whitney U–test are shown. For panels d, Pearson’s rho (r) and statistical difference (p) are indicated. ****P < 0.0001