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Table 4 Results from the Jonckheere Terpstra test evaluating the association between preoperative blood tests and tumor size, and perilobular and intralobular fibrosis, atrophy and chronic inflammation

From: Pancreatic fibrosis, acinar atrophy and chronic inflammation in surgical specimens associated with survival in patients with resectable pancreatic ductal adenocarcinoma

  No perilobular fibrosis, median
(IQR)
Mild perilobular fibrosis, median
(IQR)
Moderate perilobular fibrosis, median
(IQR)
Severe perilobular fibrosis, median
(IQR)
p
CRP (mg/l) 5.0 (7.5) 3.0 (7.5) 5.0 (7.5) 5.0 (7.5) 0.480
High-sensitivity CRP (mg/l) 5.8 (8.4) 4.0 (8.4) 3.7 (8.4) 2.9 (8.4) 0.246
Ca 19–9 (kU/l) 129.0 (556.0) 82.5 (556.0) 176.5 (556.0) 126.0 (556.0) 0.454
CEA (μg/l) 2.2 (2.7) 2.5 (2.7) 2.6 (2.7) 3.0 (2.7) 0.002
Albumin (g/l) 37.4 (5.4) 36.9 (5.4) 37.3 (5.4) 36.2 (5.4) 0.027
Tumor size (mm) 32.0 (15.0) 30.0 (15.0) 35.0 (15.0) 30.0 (15.0) 0.701
  No intralobular fibrosis, median
(IQR)
Mild intralobular fibrosis, median
(IQR)
Moderate intralobular fibrosis, median
(IQR)
Severe intralobular fibrosis, median
(IQR)
p
CRP (mg/l) 5.5 (7.5) 3.0 (7.5) 4.5 (7.5) 5.0 (7.5) 0.546
High-sensitivity CRP (mg/l) 5.2 (8.4) 4.1 (8.4) 3.2 (8.4) 3.1 (8.4) 0.403
Ca 19–9 (kU/l) 88.0 (556.0) 147.0 (556.0) 184.0 (556.0) 158.5 (556.0) 0.088
CEA (μg/l) 2.0 (2.7) 2.7 (2.7) 2.8 (2.7) 3.0 (2.7) 0.002
Albumin (g/l) 37.3 (5.4) 36.4 (5.4) 37.7 (5.4) 36.2 (5.4) 0.074
Tumor size (mm) 30.0 (15.0) 30.0 (15.0) 35.0 (15.0) 30.0 (15.0) 0.556
  No acinar atrophy, median
(IQR)
Mild acinar atrophy, median
(IQR)
Moderate acinar atrophy, median
(IQR)
Severe acinar atrophy, median
(IQR)
p
CRP (mg/l) 5.0 (7.5) 4.0 (7.5) 4.0 (7.5) 5.0 (7.5) 0.431
High-sensitivity CRP (mg/l) 4.9 (8.4) 4.1 (8.4) 3.4 (8.4) 2.6 (8.4) 0.268
Ca 19–9 (kU/l) 124.0 (556.0) 74.0 (556.0) 168.0 (556.0) 216.5 (556.0) 0.058
CEA (μg/l) 2.5 (2.7) 2.5 (2.7) 2.6 (2.7) 3.1 (2.7) 0.002
Albumin (g/l) 37.2 (5.4) 36.4 (5.4) 37.6 (5.4) 36.1 (5.4) 0.009
Tumor size (mm) 30.0 (15.0) 30.0 (15.0) 35.0 (15.0) 30.0 (15.0) 0.338
  No chronic inflammation, median
(IQR)
Mild chronic inflammation, median
(IQR)
Moderate chronic inflammation, median
(IQR)
Severe chronic inflammation, median
(IQR)
p
CRP (mg/l) 4.5 (7.5) 4.0 (7.5) 6.0 (7.5) 4.0 (7.5) 0.328
High-sensitivity CRP (mg/l) 3.2 (8.4) 3.1 (8.4) 3.5 (8.4) 2.8 (8.4) 0.964
Ca 19–9 (kU/l) 121.0 (556.0) 173.0 (556.0) 184.0 (556.0) 322.0 (556.0) 0.167
CEA (μg/l) 2.5 (2.7) 2.7 (2.7) 3.4 (2.7) 2.4 (2.7) 0.004
Albumin (g/l) 37.1 (5.4) 37.0 (5.4) 35.9 (5.4) 34.9 (5.4) 0.007
Tumor size (mm) 30.0 (15.0) 30.0 (15.0) 33.0 (15.0) 25.0 (15.0) 0.231
  1. Abbreviation: IQR interquartile range