Fig. 1

Chromatin Accessibility Distinguishes Breast Cancer Subtypes. A) UMAP dimension reduction plots depicting three distinct groups of tumors, colored by group (n=74), IHC subtype (n=69) and PAM50 subtype (n=65). B) Bar charts depicting significance of gene ontology results from Enrichr, investigating genes found to have higher and lower expression in Luminal-A tumors in group 3 compared to group 2. Adjusted p-values obtained within Enrichr. C) Heatmap showing 3 groups of chromatin regions, each showing greater accessibility in their respective tumor group compared to the rest (Lg2FC > 2.5). D) Screenshots from IGV depicting average accessibility of tumor groups in regions within each chromatin signature. E-F) Boxplots comparing chromatin signatures by regions’ distance to transcription start sites (E) and CpG density (F), with random accessible regions from the genome as a control. P-values obtained from two-tailed parametric t-tests. * is p<0.01, ** is p<0.001, *** is p<0.0001