Table 6 Multivariable analysis using logistic regressions
Factor | ORa | 95% CI | p-value |
|---|---|---|---|
Model 1: Cycle number | |||
 Cycle number | 1.44 | 1.12–1.85 | 0.004 |
Model 2: Cycle number plus chemotherapy type and factors | |||
 Cycle number | 1.51 | 1.07–2.12 | 0.018 |
 Chemotherapy type |  |  | 0.254 |
 Adjuvant vs Neoadjuvant | 0.29 | 0.02–3.55 | 0.333 |
 Palliative vs Neoadjuvant | 0.77 | 0.05–10.95 | 0.844 |
 Capecitabine | 767 × 106 | 0 - Indefinite | 1.000 |
 Cyclophosphamide | 1.80 | 0.46–7.01 | 0.400 |
 Neuropathic pain treatment | 1.18 | 0.08–18.03 | 0.904 |
Model 3: Biological measures | |||
 Hemoglobin | 0.67 | 0.45–0.99 | 0.046 |
 Leucocytes | 1.00 | 1.00–1.00 | 0.189 |
 Platelets | 1.00 | 1.00–1.00 | 0.733 |
Model 4: Genes | |||
 ABCB1 rs1045642 | 0.92 | 0.40–2.12 | 0.848 |
 CLOCK rs1801260 TT vs TC | 0.29 | 0.07–1.15 | 0.077 |
 COMT rs4680 (V/V & V/M vs M/M) | 1.37 | 0.29–6.38 | 0.693 |
 PER2 rs934945 (GG & GA) vs AA | 0.56 | 0.02–13.02 | 0.716 |
 CRY2 rs10838524 (GG & GA) vs AA | 3.12 | 0.44–21.89 | 0.253 |
 DRD2 rs6277 (CC & CT vs TT) | 4.09 | 1.02–16.48 | 0.047 |
Model 5: Full factor modela | |||
 Cycle number | 1.36 | 0.98–1.89 | 0.066 |
 CLOCK rs1801260 TT vs TC | 0.29 | 0.07–1.29 | 0.104 |
 DRD2 rs6277 (CC & CT vs TT) | 3.79 | 0.84–17.20 | 0.084 |
 Hemoglobin | 0.38 | 0.50–1.30 | 0.376 |