Fig. 5

Identification of the hub-network and hub-genes in Immunity_H subtype. A PPI network of genes in brown module which including 955 nodes and 248,141 edges. Hub-network was extracted from PPI network according to topological features and MCODE algorithm which consist of 275 nodes and 37,675 edges. B Significantly enriched KEGG pathways of hub-network genes. C Overall Survival (OS) of ADAMDEC1 in GSE62254 cohort by Kaplan-Meier (KM) analysis (log-rank P < 0.008) and external validation by GSE29272 and KMplotter cohort (log-rank P = 0.023, P = 0.031, respectively). D Overall survival of high and low ADAMDEC1 expression by Kaplan-Meier analysis in IMvigor210 cohort (Log rank test, p = 0.01). E Rate of clinical response to anti-PD-L1 immunotherapy in high and low ADAMDEC1 expression groups in IMvigor210 cohort