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Table 2 Baseline characteristics of neoadjuvant chemotherapy patients before and after PSM

From: Effectiveness and safety of pegylated liposomal doxorubicin versus epirubicin as neoadjuvant or adjuvant chemotherapy for breast cancer: a real-world study

Characteristics

Before PSM (N = 185)

After PSM (N = 86)

PLD group (N = 65)

Epirubicin group (N = 130)

P value

PLD group (N = 43)

Epirubicin group (N = 43)

P value

Age (year), n (%)

  

0.0353

  

1.0000

  < 35

15 (23.1%)

15 (11.5%)

 

10 (23.3%)

10 (23.3%)

 

  ≥ 35

50 (76.9%)

115 (88.5%)

 

33 (76.7%)

33 (76.7%)

 

Age (year), Median (range)

46 (25,70)

50 (27,67)

0.1919

49 (36–60)

48 (36–58)

0.4812

Menopausal status, n (%)

  

0.1082

  

0.2903

 Premenopausal

38 (58.5%)

64 (49.2%)

 

20 (46.5%)

27 (62.8%)

 

 Postmenopausal

22 (33.9%)

62 (47.7%)

 

18 (41.9%)

15 (34.9%)

 

 Missing

5 (7.7%)

4 (3.1%)

 

5 (11.6%)

1 (2.3%)

 

Nodal status, n (%)

  

0.0109

  

0.8122

 N0

22 (33.9%)

40 (30.8%)

 

16 (37.2%)

12 (27.9%)

 

 N1

21 (32.3%)

25 (19.2%)

 

14 (32.6%)

16 (37.2%)

 

 N2

7 (10.8%)

30 (23.1%)

 

7 (16.3%)

9 (20.9%)

 

 N3

7 (10.8%)

33 (25.4%)

 

6 (14.0%)

6 (14.0%)

 

 Missing

8 (12.3%)

2 (1.5%)

    

Tumor size, n (%)

  

0.0452

  

0.9719

 T1

14 (21.5%)

43 (33.1%)

 

14 (32.6%)

12 (27.9%)

 

 T2

30 (46.2%)

42 (32.3%)

 

24 (55.8%)

26 (60.5%)

 

 T3

4 (6.2%)

15 (11.5%)

 

3 (7.0%)

3 (7.0%)

 

 T4

2 (3.1%)

13 (10.0%)

 

2 (4.7%)

2 (4.7%)

 

 Missing

15 (23.1%)

17 (13.1%)

    

Molecular subtype, n (%)

  

0.5592

  

0.5642

 Luminal A

10 (15.4%)

18 (13.9%)

 

8 (18.6%)

5 (11.6%)

 

 Luminal B

30 (46.2%)

56 (43.1%)

 

23 (53.5%)

20 (46.5%)

 

 HER2+

6 (9.2%)

13 (10.0%)

 

4 (9.3%)

2(4.7%)

 

 BASAL-LIKE

3 (4.6%)

14 (10.8%)

 

1 (2.3%)

3 (7.0%)

 

 Missing

16 (24.6%)

29 (22.3%)

 

7 (16.3%)

13 (30.2%)

 

Ki-67 expression, n (%)

  

0.5803

  

0.7468

  < 20%

8 (12.3%)

16 (12.3%)

 

7 (16.3%)

7 (16.3%)

 

  ≥ 20%

34 (52.3%)

52 (40.0%)

 

22 (51.2%)

18 (41.9%)

 

 Missing

23 (35.4%)

62 (47.7%)

 

14 (32.6%)

18 (41.9%)

 
  1. PLD Pegylated liposomal doxorubicin