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Table 6 Univariate and multivariate Cox regression for recurrence-free survival in ICC patients after curative resection after PSM

From: Prognostic value and predication model of microvascular invasion in patients with intrahepatic cholangiocarcinoma: a multicenter study from China

Variables

Univariate

Multivariate

HR

95% CI

P-value

HR

95% CI

P-value

Age, year

1.047

0.723–1.517

0.807

   

Sex, male vs female

1.192

0.840–1.692

0.326

   

Hepatitis, no vs yes

0.899

0.620–1.302

0.572

   

Child-Pugh grade,

Grade A vs Grade B

2.004

1.273–3.153

0.003

1.601

0.991–2.586

0.055

Total bilirubin, μmol/L

< 20 vs ≥20

1.489

1.049–2.113

0.026

1.321

0.915–1.907

0.137

CA199, U/mL

< 200 vs ≥200

0.795

0.525–1.204

0.279

   

CEA, μg/L < 5 vs ≥5

1.031

0.710–1.498

0.871

   

Blood loss, ml

< 800 vs ≥800

1.086

0.730–1.617

0.683

   

Blood transfusion,

no vs yes

0.771

0.462–1.286

0.319

   

Tumor diameter, cm

≤5 vs > 5

1.650

1.089–2.501

0.018

   

Tumor number

single vs multiple

1.262

0.885–1.798

0.198

   

Surgical margin width, cm < 1 vs ≥1

0.964

0.657–1.415

0.853

   

Satellite nodules

no vs yes

1.357

0.954–1.930

0.090

   

Laparoscopy

no vs yes

0.742

0.327–1.686

0.476

   

Differentiation

moderate or high vs poor

0.619

0.407–0.942

0.025

0.727

0.474–1.116

0.145

Major hepatectomy

no vs yes

2.327

1.510–3.585

< 0.001

2.147

1.386–3.326

0.001

Hepatolith no vs yes

0.950

0.443–2.036

0.894

   

MVI no vs yes

2.038

1.433–2.898

< 0.001

2.057

1.445–2.929

< 0.001

Postoperative hospital stay, day < 15 vs ≥15

1.022

0.715–1.460

0.905

   
  1. Abbreviations: ICC Intrahepatic cholangiocarcinoma, PSM Propensity Score Matching, HR Hazard ratio, CI Confidence interval, CA199 Carbohydrate antigen 199, CEA Carcinoembryonic antigen, MVI Microvascular invasion