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Table 1 Comparison of clinicopathological characteristics between MVI-positive and negative group before PSM

From: Prognostic value and predication model of microvascular invasion in patients with intrahepatic cholangiocarcinoma: a multicenter study from China

Variables

MVI-negative group

MVI-positive group

P-value

Total

(N = 623)

(N = 81)

(N = 704)

Age, year

  < 60

369 (59.2%)

55 (67.9%)

0.168

424 (60.2%)

  ≥ 60

254 (40.8%)

26 (32.1%)

 

280 (39.8%)

Sex

 Male

365 (58.6%)

43 (53.1%)

0.410

408 (58.0%)

 Female

258 (41.4%)

38 (46.9%)

 

296 (42.0%)

Hepatitis

 No

397 (63.7%)

54 (66.7%)

0.692

451 (64.1%)

 Yes

226 (36.3%)

27 (33.3%)

 

253 (35.9%)

Child-Pugh grade

 Stage A

455 (73.0%)

69 (85.2%)

0.026

524 (74.4%)

 Stage B

168 (27.0%)

12 (14.8%)

 

180 (25.6%)

Total bilirubin, μmol/L

  ≤ 20

389 (62.4%)

49 (60.5%)

0.827

438 (62.2%)

  > 20

234 (37.6%)

32 (39.5%)

 

266 (37.8%)

CA199, U/mL

  < 200

493 (79.1%)

60 (74.1%)

0.368

553 (78.6%)

  ≥ 200

130 (20.9%)

21 (25.9%)

 

151 (21.4%)

CEA, μg/L

  < 5

488 (78.3%)

52 (64.2%)

0.007

540 (76.7%)

  ≥ 5

135 (21.7%)

29 (35.8%)

 

164 (23.3%)

Operative bleeding loss, ml

  ≥ 800

517 (83.0%)

57 (70.4%)

0.009

574 (81.5%)

  < 800

106 (17.0%)

24 (29.6%)

 

130 (18.5%)

Blood transfusion

 No

527 (84.6%)

69 (85.2%)

1.000

596 (84.7%)

 Yes

96 (15.4%)

12 (14.8%)

 

108 (15.3%)

Laparoscopy

 Yes

30 (4.8%)

5 (6.2%)

0.797

35 (5.0%)

 No

593 (95.2%)

76 (93.8%)

 

669 (95.0%)

Lymph node dissection

 No

426 (68.4%)

43 (53.1%)

0.009

469 (66.6%)

 Yes

197 (31.6%)

38 (46.9%)

 

235 (33.4%)

Major hepatectomy

 No

280 (44.9%)

24 (29.6%)

0.013

304 (43.2%)

 Yes

343 (55.1%)

57 (70.4%)

 

400 (56.8%)

Tumor diameter, cm

  ≤ 5

245 (39.3%)

22 (27.2%)

0.045

267 (37.9%)

  > 5

378 (60.7%)

59 (72.8%)

 

437 (62.1%)

Tumor number

 Single

455 (73.0%)

50 (61.7%)

0.046

505 (71.7%)

 Multiple

168 (27.0%)

31 (38.3%)

 

199 (28.3%)

Satellite nodules

 No

465 (74.6%)

48 (59.3%)

0.005

513 (72.9%)

 Yes

158 (25.4%)

33 (40.7%)

 

191 (27.1%)

Surgical margin width, cm

  < 1

432 (69.3%)

52 (64.2%)

0.417

484 (68.8%)

  ≥ 1

191 (30.7%)

29 (35.8%)

 

220 (31.2%)

Differentiation

 Moderate or high

510 (81.9%)

54 (66.7%)

0.002

564 (80.1%)

 Poor

113 (18.1%)

27 (33.3%)

 

140 (19.9%)

Lymph node metastasis

 No

533 (85.6%)

57 (70.4%)

< 0.001

590 (83.8%)

 Yes

90 (14.4%)

24 (29.6%)

 

114 (16.2%)

Hepatolith

 No

602 (96.6%)

77 (95.1%)

0.691

679 (96.4%)

 Yes

21 (3.4%)

4 (4.9%)

 

25 (3.6%)

Postoperative hospital stay, day

  < 15

366 (58.7%)

34 (42.0%)

0.006

400 (56.8%)

  ≥ 15

257 (41.3%)

47 (58.0%)

 

304 (43.2%)

  1. Abbreviations: MVI Microvascular invasion, PSM Propensity Score Matching, CA199 Carbohydrate antigen 199, CEA Carcinoembryonic antigen