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Table.2 Classification of cells in the microenvironmental niche based on immunofluorescence staining

From: High efficacy of PD-1 inhibitor after initial failure of PD-L1 inhibitor in Relapsed/Refractory classical Hodgkin Lymphoma

Patient CD68+ macrophages HRS cells Background cells
CD68 PD-L1 PD-L2 PD-L1 PD-L2 PD-1 MHC-I MHC-II PD-L1 PD-L2 PD-1 MHC-I MHC-II FOXP3 CD163
1 + - - - - - - - ++ + + ++++ Weak+ + Weak+
2 ++ + - + Weak+ - - - + Weak+ + +++ + +++ Weak+
3 + Weak+ - + Weak+ - - - + Weak+ Weak+ ++++ - + Weak+
4 + - - + ++ + +++ - + +++ + ++++ + + Weak+
5 + - + Weak+ ++ - - - Weak+ ++ +++ ++++ Weak+ ++ +