The prevalence and prognostic impact of tumor-infiltrating lymphocytes in uterine carcinosarcoma

BMC Cancer

Table 2 Clinicopathological characteristics of the sarcomatous component of carcinosarcoma and the status of intratumoral stromal CD3, CD4, CD8, FOXP3, PD-1, PD-L1 and PD-L2 (N = 57)

Clinicopathological features	Total no. of cases	CD3_S			CD4_S			CD8_S			FOXP3_S			PD-1_S			PD-L1_S			PD-L2_S
Clinicopathological features	Total no. of cases	Low	High	p-value	Low	High	p-value	Low	High	p-value	Low	High	p-value	Low	High	p-value	Low	High	p-value	Low	High	p-value
Age N = 57
< 60	17	14	3	0.503	8	9	0.124	3	14	0.795	14	3	0.924	12	5	0.827	10	7	0.118	14	3	0.924
≥ 60	40	37	3	0.503	19	11	0.124	10	30	0.795	35	5	0.924	31	9	0.827	33	7	0.118	35	5	0.924
Stage N = 57
I/II	15	12	3	0.367	11	4	0.631	5	10	0.439	12	3	0.732	10	5	0.569	10	5	0.569	13	2	1.000
III/IV	42	39	3	0.367	26	16	0.631	8	34	0.439	37	5	0.732	33	9	0.569	33	9	0.569	36	6	1.000
Histological subtype N = 42
Heterologous	30	28	2	0.909	22	8	0.957	7	23	0.418	25	5	0.834	24	6	0.647	25	5	1.000	27	3	0.940
Homologous	12	12	0	0.909	8	4	0.957	5	7	0.418	11	1	0.834	11	1	0.647	10	2	1.000	10	2	0.940
LVI N = 41
Present	25	21	4	0.252	14	11	0.625	3	22	0.266	20	5	0.844	17	8	0.567	18	7	0.434	21	4	0.760
Absent	16	16	0	0.252	11	5	0.625	5	11	0.266	14	2	0.844	13	3	0.567	14	2	0.434	12	4	0.760

Differences in absolute value correspond to missing data. Significant P-values are emboldened
LVI Lymphovascular Invasion, S Sarcomatous Component, ER Estrogen Receptor, PR Progesterone Receptor, CD3 Cluster of Differentiation 3, CD4 Cluster of Differentiation 4, CD8 Cluster of Differentiation 8, FOXP3 Forkhead Box P3, PD-1 Programmed Cell Death Protein 1, PD-L1 Programmed Death-Ligand 1, PD-L2 Programmed Death-Ligand 2

ISSN: 1471-2407