The prevalence and prognostic impact of tumor-infiltrating lymphocytes in uterine carcinosarcoma

BMC Cancer

Table 1 Clinicopathological characteristics of the epithelial component of carcinosarcoma and the status of intratumoral stromal CD3, CD4, CD8, FOXP3, PD-1, PD-L1 and PD-L2 (N = 57)

Clinicopathological features	Total no. of cases	CD3_E			CD4_E			CD8_E			FOXP3_E			PD-1_E			PD-L1_E			PD-L2_E
Clinicopathological features	Total no. of cases	Low	High	p-value	Low	High	p-value	Low	High	p-value	Low	High	p-value	Low	High	p-value	Low	High	p-value	Low	High	p-value
Age N = 57
< 60	17	6	11	0.838	2	15	0.052	3	14	0.513	11	6	0.523	7	10	0.138	5	12	0.022	1	16	0.413
≥ 60	40	13	27	0.838	15	25	0.052	12	28	0.513	30	10	0.523	25	15	0.138	25	15	0.022	7	33	0.413
Stage N = 57
I/II	15	2	13	0.038	2	13	0.025	5	10	0.584	10	5	0.697	6	9	0.138	8	7	0.587	0	15	0.041
III/IV	42	17	25	0.038	15	27	0.025	10	32	0.584	31	11	0.697	26	16	0.138	22	20	0.587	8	34	0.041
Histological subtype N = 42
Heterologous	30	9	21	0.292	12	18	0.277	8	22	0.715	23	7	0.699	18	12	0.740	21	9	0.158	5	25	0.298
Homologous	12	6	6	0.292	2	10	0.277	4	8	0.715	8	4	0.699	8	4		5	7		0	12
LVI N = 41
Present	25	4	12	1.000	3	13	0.712	7	9	0.053	12	4	0.734	13	12	0.790	13	12	0.606	4	21	1.000
Absent	16	6	19	1.000	7	18	0.712	3	22	0.053	17	8	0.734	9	7	0.790	7	9	0.606	2	14	1.000

Differences in absolute value correspond to missing data. Significant P-values are emboldened
LVI Lymphovascular Invasion, E Epithelial Component, ER Estrogen Receptor, PR Progesterone Receptor, CD3 Cluster of Differentiation 3, CD4 Cluster of Differentiation 4, CD8 Cluster of Differentiation 8, FOXP3 Forkhead Box P3, PD-1 Programmed Cell Death Protein 1, PD-L1 Programmed Death-Ligand 1, PD-L2 Programmed Death-Ligand 2

ISSN: 1471-2407