From: METTL14 gene polymorphisms decrease Wilms tumor susceptibility in Chinese children
Genotype | OR (95% CI) | Pa | Statistical power b | Prior probability | ||||
---|---|---|---|---|---|---|---|---|
0.25 | 0.1 | 0.01 | 0.001 | 0.0001 | ||||
rs1064034 T > A | ||||||||
 TA vs. TT | 0.78 (0.61–0.99) | 0.0372 | 0.899 | 0.110 | 0.271 | 0.804 | 0.976 | 0.998 |
 TA/AA vs. TT | 0.77 (0.61–0.97) | 0.0237 | 0.886 | 0.074 | 0.194 | 0.726 | 0.964 | 0.996 |
   > 18 | 0.66 (0.49–0.87) | 0.0033 | 0.441 | 0.022 | 0.063 | 0.426 | 0.882 | 0.987 |
  Females | 0.68 (0.49–0.96) | 0.0257 | 0.544 | 0.124 | 0.298 | 0.824 | 0.979 | 0.998 |
  Stage IV | 0.54 (0.29–0.997) | 0.049 | 0.255 | 0.366 | 0.634 | 0.950 | 0.995 | 0.999 |
rs298982 G > A | ||||||||
 GA vs. GG | 0.62 (0.46–0.83) | 0.0013 | 0.307 | 0.013 | 0.037 | 0.295 | 0.809 | 0.977 |
 GA/AA vs. GG | 0.69 (0.52–0.90) | 0.0071 | 0.571 | 0.036 | 0.101 | 0.552 | 0.926 | 0.992 |
   > 18 | 0.54 (0.38–0.77) | 0.0006 | 0.134 | 0.013 | 0.039 | 0.308 | 0.818 | 0.978 |
  Female | 0.59 (0.38–0.91) | 0.0167 | 0.287 | 0.149 | 0.344 | 0.852 | 0.983 | 0.998 |
  Stage I | 0.63 (0.40–0.98) | 0.0416 | 0.399 | 0.238 | 0.484 | 0.912 | 0.990 | 0.999 |
  Stage I + II | 0.69 (0.49–0.96) | 0.028 | 0.566 | 0.129 | 0.308 | 0.830 | 0.980 | 0.998 |
  Stage III + IV | 0.63 (0.40–0.98) | 0.0416 | 0.400 | 0.238 | 0.484 | 0.911 | 0.990 | 0.999 |
Protective genotypes | ||||||||
 5 vs. 0–4 | 0.68 (0.52–0.90) | 0.0063 | 0.552 | 0.033 | 0.093 | 0.531 | 0.919 | 0.991 |
   > 18 | 0.54 (0.38–0.77) | 0.0006 | 0.134 | 0.013 | 0.039 | 0.308 | 0.818 | 0.978 |
  Female | 0.60 (0.39–0.93) | 0.0216 | 0.318 | 0.169 | 0.379 | 0.871 | 0.985 | 0.999 |
  Stage I | 0.64 (0.41–0.99) | 0.0455 | 0.413 | 0.248 | 0.498 | 0.916 | 0.991 | 0.999 |
  Stage I + II | 0.69 (0.50–0.97) | 0.0318 | 0.585 | 0.140 | 0.329 | 0.843 | 0.982 | 0.998 |
  Stage III + IV | 0.61 (0.39–0.95) | 0.0291 | 0.338 | 0.205 | 0.437 | 0.895 | 0.989 | 0.999 |
Haplotypes | ||||||||
 TGGGC vs. TGAAC | 11.85 (1.37–102.72) | 0.025 | 0.035 | 0.683 | 0.866 | 0.986 | 0.999 | 1.000 |
 AGAGT vs. TGAAC | 0.39 (0.19–0.82) | 0.012 | 0.089 | 0.295 | 0.557 | 0.932 | 0.993 | 0.999 |
 TGGGC vs. TGAAC | 0.37 (0.18–0.77) | 0.008 | 0.070 | 0.256 | 0.508 | 0.919 | 0.991 | 0.999 |
 TGGGC vs. TGAAC | 0.50 (0.32–0.77) | 0.002 | 0.148 | 0.035 | 0.099 | 0.547 | 0.924 | 0.992 |