METTL14 gene polymorphisms decrease Wilms tumor susceptibility in Chinese children

Zhuo, Zhenjian; Hua, Rui-Xi; Zhang, Huizhu; Lin, Huiran; Fu, Wen; Zhu, Jinhong; Cheng, Jiwen; Zhang, Jiao; Li, Suhong; Zhou, Haixia; Xia, Huimin; Liu, Guochang; Jia, Wei; He, Jing

doi:10.1186/s12885-021-09019-5

BMC Cancer

Table 4 False-positive report probability analysis for significant findings

From: METTL14 gene polymorphisms decrease Wilms tumor susceptibility in Chinese children

Genotype	OR (95% CI)	P^a	Statistical power ^b	Prior probability
Genotype	OR (95% CI)	P^a	Statistical power ^b	0.25	0.1	0.01	0.001	0.0001
rs1064034 T > A
TA vs. TT	0.78 (0.61–0.99)	0.0372	0.899	0.110	0.271	0.804	0.976	0.998
TA/AA vs. TT	0.77 (0.61–0.97)	0.0237	0.886	0.074	0.194	0.726	0.964	0.996
> 18	0.66 (0.49–0.87)	0.0033	0.441	0.022	0.063	0.426	0.882	0.987
Females	0.68 (0.49–0.96)	0.0257	0.544	0.124	0.298	0.824	0.979	0.998
Stage IV	0.54 (0.29–0.997)	0.049	0.255	0.366	0.634	0.950	0.995	0.999
rs298982 G > A
GA vs. GG	0.62 (0.46–0.83)	0.0013	0.307	0.013	0.037	0.295	0.809	0.977
GA/AA vs. GG	0.69 (0.52–0.90)	0.0071	0.571	0.036	0.101	0.552	0.926	0.992
> 18	0.54 (0.38–0.77)	0.0006	0.134	0.013	0.039	0.308	0.818	0.978
Female	0.59 (0.38–0.91)	0.0167	0.287	0.149	0.344	0.852	0.983	0.998
Stage I	0.63 (0.40–0.98)	0.0416	0.399	0.238	0.484	0.912	0.990	0.999
Stage I + II	0.69 (0.49–0.96)	0.028	0.566	0.129	0.308	0.830	0.980	0.998
Stage III + IV	0.63 (0.40–0.98)	0.0416	0.400	0.238	0.484	0.911	0.990	0.999
Protective genotypes
5 vs. 0–4	0.68 (0.52–0.90)	0.0063	0.552	0.033	0.093	0.531	0.919	0.991
> 18	0.54 (0.38–0.77)	0.0006	0.134	0.013	0.039	0.308	0.818	0.978
Female	0.60 (0.39–0.93)	0.0216	0.318	0.169	0.379	0.871	0.985	0.999
Stage I	0.64 (0.41–0.99)	0.0455	0.413	0.248	0.498	0.916	0.991	0.999
Stage I + II	0.69 (0.50–0.97)	0.0318	0.585	0.140	0.329	0.843	0.982	0.998
Stage III + IV	0.61 (0.39–0.95)	0.0291	0.338	0.205	0.437	0.895	0.989	0.999
Haplotypes
TGGGC vs. TGAAC	11.85 (1.37–102.72)	0.025	0.035	0.683	0.866	0.986	0.999	1.000
AGAGT vs. TGAAC	0.39 (0.19–0.82)	0.012	0.089	0.295	0.557	0.932	0.993	0.999
TGGGC vs. TGAAC	0.37 (0.18–0.77)	0.008	0.070	0.256	0.508	0.919	0.991	0.999
TGGGC vs. TGAAC	0.50 (0.32–0.77)	0.002	0.148	0.035	0.099	0.547	0.924	0.992

OR Odds ratio, CI Confidence interval
^aChi-square test was used to calculate the genotype frequency distributions
^bStatistical power was calculated using the number of observations in each subgroup and the corresponding ORs and P values in this table

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ISSN: 1471-2407

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