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Table 3 The frequency of inferred haplotypes of METTL14 gene based on observed genotypes and their association with the risk of Wilms tumor

From: METTL14 gene polymorphisms decrease Wilms tumor susceptibility in Chinese children

Haplotypes a

Cases (n = 806)

Controls (n = 2396)

Crude OR (95% CI)

P

Adjusted OR b (95% CI)

Pb

TGAAC

78 (9.68)

233 (9.72)

1.00

 

1.00

 

TGAAT

41 (5.09)

111 (4.63)

0.88 (0.57–1.34)

0.542

0.87 (0.57–1.33)

0.516

TGAGC

209 (25.93)

550 (22.95)

0.90 (0.68–1.20)

0.468

0.90 (0.68–1.19)

0.464

TGAGT

242 (30.02)

744 (31.05)

0.77 (0.59–1.02)

0.064

0.77 (0.59–1.02)

0.066

TGGAT

4 (0.50)

0 (0.00)

/

/

/

/

TGGGC

5 (0.62)

1 (0.04)

11.85 (1.37–102.72)

0.025

11.15 (1.28–96.76)

0.029

TGGGT

3 (0.37)

1 (0.04)

7.11 (0.73–69.18)

0.091

7.50 (0.77–73.05)

0.083

TAAAT

1 (0.12)

0 (0.00)

/

/

/

/

TAAGC

1 (0.12)

0 (0.00)

/

/

/

/

AGGAT

23 (2.85)

79 (3.30)

0.69 (0.41–1.16)

0.162

0.70 (0.41–1.16)

0.172

AGGGC

65 (8.06)

193 (8.06)

0.80 (0.55–1.15)

0.227

0.80 (0.55–1.15)

0.221

AGGGT

23 (2.85)

69 (2.88)

0.79 (0.47–1.34)

0.380

0.80 (0.47–1.36)

0.417

AGAAC

3 (0.37)

0 (0.00)

/

/

/

/

AGAAT

2 (0.25)

1 (0.04)

4.74 (0.43–52.87)

0.206

5.23 (0.47–58.94)

0.180

AGAGC

1 (0.12)

1 (0.04)

2.37 (0.15–38.27)

0.543

2.46 (0.15–39.70)

0.527

AGAGT

9 (1.12)

55 (2.30)

0.39 (0.19–0.82)

0.012

0.40 (0.19–0.84)

0.016

AAGAC

1 (0.12)

0 (0.00)

/

/

/

/

AAGGC

2 (0.25)

2 (0.08)

2.37 (0.33–17.06)

0.392

2.32 (0.32–16.75)

0.403

AAGGT

9 (1.12)

58 (2.42)

0.37 (0.18–0.77)

0.008

0.38 (0.18–0.80)

0.010

AAAAC

0 (0.00)

2 (0.08)

/

/

/

/

AAAAT

18 (2.23)

70 (2.92)

0.61 (0.35–1.08)

0.088

0.62 (0.35–1.09)

0.096

AAAGC

34 (4.22)

162 (6.76)

0.50 (0.32–0.77)

0.002

0.50 (0.32–0.77)

0.002

AAAGT

32 (3.97)

64 (2.67)

1.19 (0.73–1.92)

0.492

1.19 (0.73–1.93)

0.488

  1. aThe haplotypes order were rs1064034, rs298982, rs62328061, rs9884978, and rs4834698
  2. bObtained in logistic regression models with adjustment for age and gender