Table 1 Association between METTL14 gene polymorphisms and Wilms tumor susceptibility
From: METTL14 gene polymorphisms decrease Wilms tumor susceptibility in Chinese children
Genotype | Cases (N = 403) | Controls (N = 1198) | Pa | Crude OR (95% CI) | P | Adjusted OR (95% CI) b | Pb |
|---|---|---|---|---|---|---|---|
rs1064034 T > A (HWE = 0.715) | |||||||
 TT | 216 (53.60) | 564 (47.08) |  | 1.00 |  | 1.00 |  |
 TA | 152 (37.72) | 512 (42.74) |  | 0.78 (0.61–0.99) | 0.037 | 0.78 (0.61–0.99) | 0.041 |
 AA | 35 (8.68) | 122 (10.18) |  | 0.75 (0.50–1.13) | 0.164 | 0.76 (0.51–1.15) | 0.198 |
 Additive |  |  | 0.035 | 0.83 (0.70–0.99) | 0.035 | 0.83 (0.70–0.995) | 0.044 |
 Dominant | 187 (46.40) | 634 (52.92) | 0.024 | 0.77 (0.61–0.97) | 0.024 | 0.78 (0.62–0.97) | 0.029 |
 Recessive | 368 (91.32) | 1076 (89.82) | 0.382 | 0.84 (0.57–1.24) | 0.382 | 0.86 (0.58–1.27) | 0.438 |
rs298982 G > A (HWE = 0.155) | |||||||
 GG | 321 (79.65) | 873 (72.87) |  | 1.00 |  | 1.00 |  |
 GA | 66 (16.38) | 292 (24.37) |  | 0.62 (0.46–0.83) | 0.001 | 0.62 (0.46–0.84) | 0.002 |
 AA | 16 (3.97) | 33 (2.75) |  | 1.32 (0.72–2.43) | 0.375 | 1.32 (0.72–2.43) | 0.373 |
 Additive |  |  | 0.061 | 0.80 (0.64–1.01) | 0.061 | 0.81 (0.64–1.02) | 0.071 |
 Dominant | 82 (20.35) | 325 (27.13) | 0.007 | 0.69 (0.52–0.90) | 0.007 | 0.69 (0.53–0.91) | 0.009 |
 Recessive | 387 (96.03) | 1165 (97.25) | 0.220 | 1.46 (0.80–2.68) | 0.223 | 1.46 (0.79–2.68) | 0.225 |
rs62328061 A > G (HWE = 0.819) | |||||||
 AA | 281 (69.73) | 830 (69.28) |  | 1.00 |  | 1.00 |  |
 AG | 109 (27.05) | 333 (27.80) |  | 0.97 (0.75–1.25) | 0.796 | 0.97 (0.75–1.25) | 0.812 |
 GG | 13 (3.23) | 35 (2.92) |  | 1.10 (0.57–2.10) | 0.780 | 1.12 (0.58–2.15) | 0.736 |
 Additive |  |  | 0.963 | 1.00 (0.81–1.23) | 0.963 | 1.00 (0.81–1.24) | 0.998 |
 Dominant | 122 (30.27) | 368 (30.72) | 0.867 | 0.98 (0.77–1.25) | 0.867 | 0.98 (0.77–1.26) | 0.894 |
 Recessive | 390 (96.77) | 1163 (97.08) | 0.757 | 1.11 (0.58–2.12) | 0.757 | 1.13 (0.59–2.16) | 0.714 |
rs9884978 G > A (HWE = 0.412) | |||||||
 GG | 252 (62.53) | 758 (63.27) |  | 1.00 |  | 1.00 |  |
 GA | 131 (32.51) | 384 (32.05) |  | 1.03 (0.80–1.31) | 0.836 | 1.03 (0.81–1.31) | 0.826 |
 AA | 20 (4.96) | 56 (4.67) |  | 1.07 (0.63–1.83) | 0.791 | 1.06 (0.62–1.80) | 0.826 |
 Additive |  |  | 0.759 | 1.03 (0.85–1.25) | 0.757 | 1.03 (0.85–1.25) | 0.773 |
 Dominant | 151 (37.47) | 440 (36.73) | 0.790 | 1.03 (0.82–1.30) | 0.789 | 1.03 (0.82–1.30) | 0.791 |
 Recessive | 383 (95.04) | 1142 (95.33) | 0.814 | 1.07 (0.63–1.80) | 0.814 | 1.05 (0.62–1.78) | 0.851 |
rs4834698 T > C (HWE = 0.827) | |||||||
 TT | 107 (26.55) | 329 (27.46) |  | 1.00 |  | 1.00 |  |
 TC | 193 (47.89) | 594 (49.58) |  | 1.00 (0.76–1.31) | 0.995 | 0.99 (0.75–1.30) | 0.921 |
 CC | 103 (25.56) | 275 (22.95) |  | 1.15 (0.84–1.58) | 0.379 | 1.14 (0.83–1.56) | 0.425 |
 Additive |  |  | 0.392 | 1.07 (0.92–1.26) | 0.392 | 1.07 (0.91–1.25) | 0.438 |
 Dominant | 296 (73.45) | 869 (72.54) | 0.722 | 1.05 (0.81–1.35) | 0.724 | 1.03 (0.80–1.34) | 0.798 |
 Recessive | 300 (74.44) | 923 (77.05) | 0.287 | 1.15 (0.89–1.50) | 0.287 | 1.15 (0.88–1.49) | 0.304 |
Combined effect of protective genotypes c | |||||||
 0–4 | 322 (79.90) | 875 (73.04) |  | 1.00 |  | 1.00 |  |
 5 | 81 (20.10) | 323 (26.96) | 0.006 | 0.68 (0.52–0.90) | 0.006 | 0.69 (0.52–0.91) | 0.008 |