Description | Gene makers | Breast cancer | |||
---|---|---|---|---|---|
None | Purity | ||||
Cor | P | partial.cor | partial.p | ||
CD8 + T cell | CD8A | − 0.022 | 4.75 × 10–1 | 0.04686004 | 0.13985143 |
CD8B | − 0.148 | 8.28 × 10–7*** | − 0.10188943 | 0.00129684* | |
T cell (general) | CD3D | −0.125 | 3.09 × 10–5*** | −0.06614794 | 0.03705509* |
CD3E | −0.094 | 1.82 × 10–3* | −0.02731704 | 0.38961155 | |
CD2 | −0.043 | 1.5 × 10–1 | 0.02692737 | 0.3964128 | |
B cell | CD19 | −0.146 | 1.08 × 10–6*** | −0.09601416 | 0.00244306* |
CD79A | −0.136 | 5.99 × 10–6*** | −0.0761307 | 0.01636396* | |
Monocyte | CD86 | 0.096 | 1.47 × 10–3* | 0.15738691 | 6.1348E-07*** |
CD115(CSF1R) | 0.001 | 9.73 × 10–1 | 0.0607296 | 0.05561681 | |
TAM | CCL2 | 0.002 | 9.39 × 10–1 | 0.06986978 | 0.02761177* |
CD68 | 0.065 | 3.01 × 10–2 | 0.11656366 | 0.00023057** | |
IL10 | 0.153 | 3.38 × 10–7*** | 0.21721067 | 4.4418E-12*** | |
M1 Macrophage | INOS (NOS2) | −0.024 | 4.34 × 10–1 | −0.0130669 | 0.68072849 |
IRF5 | 0.016 | 5.91 × 10–1 | 0.03883945 | 0.22116287 | |
COX2(PTGS2) | 0.043 | 1.56 × 10–1 | 0.12822816 | 5.0261E-05*** | |
M2 Macrophage | CD163 | 0.152 | 4.1 × 10–7*** | 0.20522705 | 6.4959E-11*** |
VSIG4 | 0.077 | 1.04 × 10–2 | 0.12544706 | 7.3161E-05*** | |
MS4A4A | 0.138 | 4.39 × 10–6*** | 0.210251 | 2.1511E-11*** | |
Neutrophils | CD66b(CEACAM8) | −0.018 | 5.52 × 10–1 | −0.01102645 | 0.72843176 |
CD11b(ITGAM) | 0.041 | 1.76 × 10–1 | 0.08676308 | 0.00619708* | |
CCR7 | −0.055 | 6.61 × 10–2 | 0.0154633 | 0.62630164 | |
Natural killer cell | KIR2DL1 | −0.015 | 6.12 × 10–1 | 0.00357961 | 0.9102562 |
KIR2DL3 | −0.008 | 7.97 × 10–1 | 0.0146039 | 0.64560698 | |
KIR2DL4 | −0.027 | 3.62 × 10–1 | 0.00685601 | 0.8290771 | |
KIR3DL1 | −0.04 | 1.82 × 10–1 | −0.00907876 | 0.77497103 | |
KIR3DL2 | −0.051 | 9.37 × 10–2 | −0.01393341 | 0.66083692 | |
KIR3DL3 | 0.004 | 8.82 × 10–1 | 0.01473616 | 0.64262004 | |
KIR2DS4 | −0.028 | 3.57 × 10–1 | 0.01435843 | 0.65116604 | |
Dendritic cell | HLA-DPB1 | −0.167 | 2.46 × 10–8*** | −0.11866431 | 0.000177** |
HLA-DQB1 | −0.113 | 1.75 × 10–4** | −0.05129112 | 0.10606764 | |
HLA-DRA | 0.011 | 7.1 × 10–1 | 0.08384234 | 0.0081765* | |
HLA-DPA1 | 0.011 | 7.12 × 10–1 | 0.08372552 | 0.00826629* | |
BCDA-1(CD1C) | −0.083 | 5.95 × 10–3* | −0.0070813 | 0.82355157 | |
BCDA-4(NRP1) | 0.144 | 1.59 × 10–6*** | 0.20736387 | 4.0736E-11*** | |
CD11c(ITGAX) | −0.02 | 5.17 × 10–1 | 0.04743547 | 0.1350466 | |
Th1 | T-bet (TBX21) | −0.096 | 1.45 × 10–3* | −0.03946619 | 0.21379428 |
STAT4 | 0.024 | 4.34 × 10–1 | 0.10698215 | 0.00072919** | |
STAT1 | 0.275 | 1.62 × 10–20*** | 0.29435209 | 2.558E-21*** | |
IFN-γ (IFNG) | −0.033 | 2.75 × 10–1 | 0.0081502 | 0.79745787 | |
TNF-α (TNF) | −0.068 | 2.51 × 10–2 | −0.03221895 | 0.31021222 | |
Th2 | GATA3 | 0.301 | 1.66 × 10–24*** | 0.27086187 | 3.5639E-18*** |
STAT6 | 0.075 | 1.32 × 10–2 | 0.10105935 | 0.00142107* | |
STAT5A | 0.001 | 9.78 × 10–1 | 0.04334184 | 0.17212936 | |
IL13 | −0.009 | 7.67 × 10–1 | 0.02091229 | 0.51017828 | |
Tfh | BCL6 | 0.062 | 4.01 × 10–2 | 0.10660096 | 0.00076196** |
IL21 | 0.041 | 1.71 × 10–1 | 0.07605566 | 0.01647037* | |
Th17 | STAT3 | 0.304 | 5.92 × 10–25*** | 0.31529031 | 2.2229E-24*** |
IL17A | −0.007 | 8.23 × 10–1 | 0.01164907 | 0.71375374 | |
Treg | FOXP3 | 0.006 | 8.53 × 10–1 | 0.07298812 | 0.02137316* |
CCR8 | 0.217 | 3.19 × 10–13*** | 0.27040878 | 4.0704E-18*** | |
STAT5B | 0.254 | 1.35 × 10–17*** | 0.27303179 | 1.8794E-18*** | |
TGFβ (TGFB1) | −0.093 | 1.95 × 10–3* | −0.0489941 | 0.12267125 | |
T cell exhaustion | PD-1(PDCD1) | −0.142 | 2.14 × 10–6*** | −0.09726802 | 0.00214011* |
CTLA4 | −0.037 | 2.15 × 10–1 | 0.02018994 | 0.52490196 | |
LAG3 | −0.14 | 3.09 × 10–6*** | −0.11585047 | 0.00025198** | |
TIM-3(HAVCR2) | 0.133 | 9.24 × 10–6*** | 0.18444976 | 4.6761E-09*** | |
GZMB | −0.084 | 5.49 × 10–3* | −0.03822992 | 0.22850157 |