Table 1 Correlation analysis between eIF4E and relate genes and markers of immune cells in TIMER

CD8 + T cell

CD8A

− 0.022

4.75 × 10–1

0.04686004

0.13985143

CD8B

− 0.148

8.28 × 10–7^***

− 0.10188943

0.00129684^*

T cell (general)

CD3D

−0.125

3.09 × 10–5^***

−0.06614794

0.03705509^*

CD3E

−0.094

1.82 × 10–3^*

−0.02731704

0.38961155

CD2

−0.043

1.5 × 10–1

0.02692737

0.3964128

B cell

CD19

−0.146

1.08 × 10–6^***

−0.09601416

0.00244306^*

CD79A

−0.136

5.99 × 10–6^***

−0.0761307

0.01636396^*

Monocyte

CD86

0.096

1.47 × 10–3^*

0.15738691

6.1348E-07^***

CD115(CSF1R)

0.001

9.73 × 10–1

0.0607296

0.05561681

TAM

CCL2

0.002

9.39 × 10–1

0.06986978

0.02761177^*

CD68

0.065

3.01 × 10–2

0.11656366

0.00023057^**

IL10

0.153

3.38 × 10–7^***

0.21721067

4.4418E-12^***

M1 Macrophage

INOS (NOS2)

−0.024

4.34 × 10–1

−0.0130669

0.68072849

IRF5

0.016

5.91 × 10–1

0.03883945

0.22116287

COX2(PTGS2)

0.043

1.56 × 10–1

0.12822816

5.0261E-05^***

M2 Macrophage

CD163

0.152

4.1 × 10–7^***

0.20522705

6.4959E-11^***

VSIG4

0.077

1.04 × 10–2

0.12544706

7.3161E-05^***

MS4A4A

0.138

4.39 × 10–6^***

0.210251

2.1511E-11^***

Neutrophils

CD66b(CEACAM8)

−0.018

5.52 × 10–1

−0.01102645

0.72843176

CD11b(ITGAM)

0.041

1.76 × 10–1

0.08676308

0.00619708^*

CCR7

−0.055

6.61 × 10–2

0.0154633

0.62630164

Natural killer cell

KIR2DL1

−0.015

6.12 × 10–1

0.00357961

0.9102562

KIR2DL3

−0.008

7.97 × 10–1

0.0146039

0.64560698

KIR2DL4

−0.027

3.62 × 10–1

0.00685601

0.8290771

KIR3DL1

−0.04

1.82 × 10–1

−0.00907876

0.77497103

KIR3DL2

−0.051

9.37 × 10–2

−0.01393341

0.66083692

KIR3DL3

0.004

8.82 × 10–1

0.01473616

0.64262004

KIR2DS4

−0.028

3.57 × 10–1

0.01435843

0.65116604

Dendritic cell

HLA-DPB1

−0.167

2.46 × 10–8^***

−0.11866431

0.000177^**

HLA-DQB1

−0.113

1.75 × 10–4^**

−0.05129112

0.10606764

HLA-DRA

0.011

7.1 × 10–1

0.08384234

0.0081765^*

HLA-DPA1

0.011

7.12 × 10–1

0.08372552

0.00826629^*

BCDA-1(CD1C)

−0.083

5.95 × 10–3^*

−0.0070813

0.82355157

BCDA-4(NRP1)

0.144

1.59 × 10–6^***

0.20736387

4.0736E-11^***

CD11c(ITGAX)

−0.02

5.17 × 10–1

0.04743547

0.1350466

Th1

T-bet (TBX21)

−0.096

1.45 × 10–3^*

−0.03946619

0.21379428

STAT4

0.024

4.34 × 10–1

0.10698215

0.00072919^**

STAT1

0.275

1.62 × 10–20^***

0.29435209

2.558E-21^***

IFN-γ (IFNG)

−0.033

2.75 × 10–1

0.0081502

0.79745787

TNF-α (TNF)

−0.068

2.51 × 10–2

−0.03221895

0.31021222

Th2

GATA3

0.301

1.66 × 10–24^***

0.27086187

3.5639E-18^***

STAT6

0.075

1.32 × 10–2

0.10105935

0.00142107^*

STAT5A

0.001

9.78 × 10–1

0.04334184

0.17212936

IL13

−0.009

7.67 × 10–1

0.02091229

0.51017828

Tfh

BCL6

0.062

4.01 × 10–2

0.10660096

0.00076196^**

IL21

0.041

1.71 × 10–1

0.07605566

0.01647037^*

Th17

STAT3

0.304

5.92 × 10–25^***

0.31529031

2.2229E-24^***

IL17A

−0.007

8.23 × 10–1

0.01164907

0.71375374

Treg

FOXP3

0.006

8.53 × 10–1

0.07298812

0.02137316^*

CCR8

0.217

3.19 × 10–13^***

0.27040878

4.0704E-18^***

STAT5B

0.254

1.35 × 10–17^***

0.27303179

1.8794E-18^***

TGFβ (TGFB1)

−0.093

1.95 × 10–3^*

−0.0489941

0.12267125

T cell exhaustion

PD-1(PDCD1)

−0.142

2.14 × 10–6^***

−0.09726802

0.00214011^*

CTLA4

−0.037

2.15 × 10–1

0.02018994

0.52490196

LAG3

−0.14

3.09 × 10–6^***

−0.11585047

0.00025198^**

TIM-3(HAVCR2)

0.133

9.24 × 10–6^***

0.18444976

4.6761E-09^***

GZMB

−0.084

5.49 × 10–3^*

−0.03822992

0.22850157