Factor | LNM- (n = 289) | LNM+ (n = 65) | LNM% | Relative risk (CI 95%) | P-value |
---|---|---|---|---|---|
Age (years) | 56.74 ± 11.084 | 54.80 ± 12.677 | 0.301 | ||
< 40 | 16 | 10 | 38.46% | 2.297 (1.333–3.947) | 0.006 |
≥ 40 | 273 | 55 | 16.77% | ||
Sex | 0.373 | ||||
Male | 186 | 38 | 16.96% | ||
Female | 103 | 27 | 20.77% | ||
BMI (kg/m2) | 21.08 ± 5.914 | 21.24 ± 5.782 | 0.874 | ||
Size (cm) | |||||
Length-diameter | 2.091 ± 1.198 | 2.930 ± 1.689 | 0.009 | ||
Short-diameter | 1.713 ± 1.126 | 2.196 ± 1.342 | 0.068 | ||
< 2 cm | 152 | 26 | 14.61% | 1.712 (0.924–3.174) | 0.076 |
≥ 2 cm | 137 | 39 | 22.16% | ||
< 3 cm | 236 | 39 | 14.18% | 2.496 (1.532–4.065) | < 0.001 |
≥ 3 cm | 53 | 26 | 32.91% | ||
Tumor marker | |||||
CEA (U/mL) | 7.032 ± 81.39 | 4.394 ± 9.618 | 0.631 | ||
CA125 (U/mL) | 10.31 ± 9.527 | 9.995 ± 5.774 | 0.566 | ||
CA199 (U/mL) | 13.689 ± 59.54 | 17.703 ± 45.017 | 0.526 | ||
Location | |||||
Upper | 27 | 6 | 18.18% | 0.765 | |
Middle | 136 | 28 | 17.07% | ||
Lower | 142 | 31 | 17.92% | ||
Depth of invasion | |||||
Tis | 41 | 1 | 2.38% | < 0.001 | |
T1a | 152 | 25 | 14.12% | ||
T1b | 98 | 37 | 27.41% | ||
Differentiation | |||||
Well/Moderate | 155 | 14 | 8.28% | < 0.001 | |
Poorly | 134 | 51 | 27.57% | 3.328 (1.914–5.787) | |
Ulcer finding | |||||
Absent | 133 | 36 | 21.30% | 0.172 | |
Present | 156 | 29 | 15.68% | ||
Number of lymph nodes | 36.97 ± 24.157 | 40.63 ± 18.23 | 0.864 | ||
LVI | |||||
Absent | 283 | 55 | 16.27% | < 0.001 | |
Present | 6 | 10 | 62.5% | 3.751 (2.422–5.809) | |
Recurrence | 7 | 2 | |||
OS ratea | 94.54% | 80.77% | 0.021 | ||
DFS ratea | 93.64% | 79.17% | 0.011 |